Results 191 to 200 of about 1,109,048 (266)

Regulation of the endoplasmic reticulum stress sensor ATF6α through multiple oxidoreductases in the ER. [PDF]

iScience
Wada S, Uegaki K, Nagata K, Ushioda R.
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Characterization of an AsnC/Lrp-family transcriptional regulator in <i>Herbaspirillum rubrisubalbicans</i> M1: linking plant interaction, nitrogen response and PHB metabolism. [PDF]

Front Microbiol
Chaves RBR, Alves LPS, de Lima Nichio BT, Tuleski TR, Baura VA, Muller-Santos M, Tomazini E, Sampaio A, Souza EM, Monteiro RA.   +9 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Functional Analysis of <i>ZmABA8ox1b</i> in Regulating Maize Seed Germination via ABA Catabolism and Multi-Hormone Signaling Crosstalk. [PDF]

Plants (Basel)
Wang C, Li Y, Hao N, Sun L, Sun N, Wang Y, Zhang Y, Zhao S, Ye Y.   +8 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

The 3'Untranslated region is a critical determinant of Getah virus replication, pathogenesis, and vector competence. [PDF]

Virulence
Ren T, Li P, Liu M, Zhang L, Zhong Z, Wang G, Wang X, Zhou L, Qin Y, Ouyang K, Yin Y, Chen Y, Huang W, Wei Z.   +13 more
europepmc   +1 more source