Results 181 to 190 of about 1,964,495 (300)

Downregulation of motility during stress requires stressosome input in <i>Listeria monocytogenes</i> strain EGD-e. [PDF]

Appl Environ Microbiol
Tiensuu T, Guerreiro DN, Ignatov D, Oliveira AH, O'Byrne C, Johansson J.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Polarisome core component FgPea2 regulates FgBoi2-mediated polarized growth, pathogenicity and environmental stress in Fusarium graminearum. [PDF]

Stress Biol
Guo X, Li P, Xiao Y, Liang J, Zheng C, Huang C, Abubakar YS, Wang Z, Zheng H, Yan J, Lu GD.   +10 more
europepmc   +1 more source

Mutant Ninja viruses [PDF]

Hepatology, 2015
openaire   +2 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response. [PDF]

Proc Natl Acad Sci U S A
Parenti NA, Cusic R, Renner DM, Jackson N, Ye C, Tan LH, Pfannenstiel JJ, Fehr AR, Cohen NA, Martinez-Sobrido L, Burke JM, Weiss SR.   +11 more
europepmc   +1 more source

Repressing mutant proteins [PDF]

Nature Reviews Neuroscience, 2019
openaire   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Targeted mutagenesis in Ehrlichia canis deleting the phage head-to-tail connector protein gene and its assessment as a vaccine candidate preventing canine ehrlichiosis. [PDF]

Vaccine
Ferm DD, Nair A, Ferm JD, Liu H, Wang Y, Crosby LF, McGill J, De Late PL, Stoll I, Chauhan D, Choudhury D, Madesh S, Ganta S, Burne A, Ozubek S, Yadav A, Ganta RR.   +16 more
europepmc   +1 more source

Walnut Mutant Investigations [PDF]

Proceedings of the National Academy of Sciences, 1915
openaire   +2 more sources