Results 261 to 270 of about 2,159,893 (336)

Functional Characterization of a Lassa Virus Fusion Inhibitor Adaptive Mutant [PDF]

Jiao Guo, Guangshun Zhang, Yang Liu, Junyuan Cao, Mengmeng Zhang, Xiaohao Lan, Yueli Zhang, Chenchen Liu, Gengfu Xiao, Wei Wang   +9 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Hydrogen-deuterium exchange reveals catalytically linked protein flexibility in myoglobin-mediated intramolecular C(sp³)-H activation. [PDF]

Protein Sci
Gao H, Camargo EA, Ubi JN, Duan X, Tian X, Deng H, Zheng G, Gao S.   +7 more
europepmc   +1 more source

Comparative Clinical-Imaging and Histogenetic Analysis Between Astrocytoma IDH-Mutant Grade 4 and Glioblastoma IDH-Wildtype—Is There Really a Worse One? [PDF]

Cristian Ionuţ Orǎșanu, Mariana Aşchie, Mariana Deacu, Mǎdǎlina Boşoteanu, Sorin Vameşu, Manuela Enciu, Georgeta Camelia Cozaru, Anca Florentina Mitroi, Sinziana Andra Ghitoi, Ana Maria Cretu, Oana Andreea Ursica, Raluca Ioana Vodă   +11 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Early Cytoskeletal Remodeling Drives Hypertrophic Cardiomyopathy Pathogenesis in <i>MYH6/7</i> Mutant hiPSC-Derived Cardiomyocytes. [PDF]

J Cardiovasc Dev Dis
Shameem M, Salih H, Sharara A, John RNR, Ogle L, Singh BN.   +5 more
europepmc   +1 more source

MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos [PDF]

Clayton M. Carey, Saba Parvez, Zachary J. Brandt, Brent W. Bisgrove, Christopher J. Yates, Randall T. Peterson, James A. Gagnon   +6 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Synthetic essentiality of isoprenylcysteine carboxylmethyltransferase in PTEN deficient triple negative breast cancer. [PDF]

Exp Hematol Oncol
Park BS, Kim J, Seo DC, Choi GE, Seo JJ, Lee SE, Kim T.   +6 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source