Results 261 to 270 of about 2,114,568 (336)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

The impact of CP12 on the metabolome of cyanobacteria under fluctuating CO₂ conditions. [PDF]

Front Plant Sci
Lucius S, Arrivault S, Feil R, Alvarenga-Lucius L, Hagemann M.   +4 more
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus. [PDF]

Transl Psychiatry
Perzel Mandell KA, Simmons SK, Nadig A, Farsi Z, Huang WC, Aryal S, Kwon MJ, Song B, Brenner K, Shepard N, Nicolella AA, O'Brien LD, Lichtman AH, Levin JZ, Sheng M.   +14 more
europepmc   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Exploration of schizophrenia-related behavioral and molecular abnormalities in a mutant mouse model with a mutation in the TVV motif of the ErbB4 gene. [PDF]

Mol Brain
Khan AA, Wang S, Wang Z, Rehman Z, Chen L, Kuang Y, Zhang X, Li Y, Yang J, Ye J, Ma X, Zhao Q, Ding Y, Suzuki T, Lan Z, Li W.   +15 more
europepmc   +1 more source

A sterile and extremely dwarf mutant occurred in a theoretically pure line of rice

, 1942
盛永 俊太郎, 栗山 英雄, 青木 政春   +2 more
openalex   +2 more sources

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

IDH mutant high-grade gliomas. [PDF]

Front Mol Neurosci
Valvi S, Fouladi M, Fisher MJ, Gottardo NG.   +3 more
europepmc   +1 more source

A Serological Study on Pseudomonas Aeruginosa Rep. 1. Especially on the Antigenic Structure of Some Mutants Strains of Pseudomonas Aeruginosa

, 1959
Nobuko Matsui
openalex   +2 more sources