Results 281 to 290 of about 2,913,254 (384)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Characteristics of H3 K27M-mutant gliomas in adults

Neuro-Oncology, 2017
D. Meyronet, Maud Esteban-Mader, C. Bonnet, M. Joly, E. Uro-Coste, A. Amiel-Benouaich, Fabien Forest, C. Rousselot-Denis, F. Burel-Vandenbos, V. Bourg, J. Guyotat, T. Fenouil, A. Jouvet, J. Honnorat, F. Ducray   +14 more
semanticscholar   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Progressive mural cell deficiencies across the lifespan in a <i>foxf2</i> model of cerebral small vessel disease. [PDF]

Elife
Graff MFE, Heeg EEM, Elliott DA, Childs SJ.   +3 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The complex subunit VdAP-2α regulates polar growth, ergosterol metabolism, and virulence in <i>Verticillium dahliae</i>. [PDF]

Virulence
Wang YH, Zhu D, Wang D, Sheng RC, Wang LC, Zhang CN, Latif MF, Li H, Chen FM.   +8 more
europepmc   +1 more source

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome.

Cell, 2004
K. Olive, D. Tuveson, Zachary C Ruhe, Bob Yin, Nicholas A. Willis, R. Bronson, D. Crowley, T. Jacks   +7 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A remote surface loop modulates core structure and cold activity in phosphopantetheine adenylyltransferase. [PDF]

PLoS One
Nam Y, Hwang J, Kim B, Lee JH, Do H.
europepmc   +1 more source