Results 291 to 300 of about 2,159,893 (336)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

PRDM16 expression is an independent prognostic factor in AML with the double-mutant NPM1/FLT3-ITD genotype. [PDF]

Ann Hematol
Stasik S, Eckardt JN, Röllig C, Baldus CD, Serve H, Müller-Tidow C, Schäfer-Eckart K, Kaufmann M, Krause SW, Hänel M, Neubauer A, Ehninger G, Platzbecker U, Bornhäuser M, Schetelig J, Middeke JM, Thiede C.   +16 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Identification of biofilm-associated genes in <i>Arcobacter butzleri</i>. [PDF]

Biofilm
Salazar-Sánchez A, Ghigo JM, Martínez-Ballesteros I, Martinez-Malaxetxebarria I.   +3 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

CHEK2 loss endows chemotherapy resistance to hematopoietic stem cells. [PDF]

Leukemia
Zhou J, Hu T, Li D, Li S, Li M, Shi X, Nakada D.   +6 more
europepmc   +1 more source

Dysregulation of ERAD and Stress Response Proteins by V493F FTO Over-expression: A Proteomic Perspective. [PDF]

In Vivo
Kanli A.
europepmc   +1 more source

Sesquiterpene Biosynthetic Gene vir4 from Trichoderma virens Enhances Direct Herbivore Resistance while Maintaining Indirect Defense. [PDF]

J Chem Ecol
Nawakht NA, Mendoza-Mendoza A, Rostás M.   +2 more
europepmc   +1 more source

Mutant

, 1966
openaire   +1 more source

Reviewer #1 (Public review): Genetic compensation in podocalyxin-like mutants during zebrafish liver development

Alexis N Ross, Natalie M Miscik, Sharanya Maanasi Kalasekar, James D Harris, Mimi Tran, Aavrati Saxena, Steven Andrew Baker, Kimberley Jane Evason   +7 more
openalex   +1 more source