Results 301 to 310 of about 2,828,087 (336)

Spatiotemporal localization of jasmonate in the regulation of fruit set in tomato. [PDF]

J Exp Bot
Nomura Y, Lu Y, Harada K, Enomoto H, Yano R, Ezura K, Kojima M, Takebayashi Y, Sakakibara H, Ezura H, Ariizumi T.   +10 more
europepmc   +1 more source

Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial

Jonathan W. Goldman, A. Martinez Bueno, Christophe Dooms, Komal Jhaveri, Maria J. de Miguel, Sarina A. Piha‐Paul, Nisha Unni, Aviad Zick, Amit Mahipal, Jennifer M. Suga, Charles Naltet, M. Antoñanzas, John Crown, Judith D. Bebchuk, Lisa D. Eli, Barbara Lowenthal, Devalingam Mahalingam   +16 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A scoping review of antimalarial drug resistance markers in Kenya (1987-2022): toward a National Surveillance Framework and Data Repository. [PDF]

Malar J
Wamae K, Magudha J, Asiimwe E, Kimani K, Kandie R, Keitany K, Snow RW, Ochola-Oyier LI.   +7 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

An EAAT2b/SLC1A2b-mediated chloride leak current enables rapid cone photoreceptor signalling. [PDF]

Open Biol
Zang J, Niklaus S, Neuhauss SCF.
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

ATG-3 limits Orsay virus infection in C. elegans and regulates collagen pathways. [PDF]

PLoS Pathog
Kalugotla G, Marmerstein V, Schriefer LA, Wang L, Morrison SA, Perez LC, Silverman GA, Schedl T, Pak SC, Baldridge MT.   +9 more
europepmc   +1 more source