Results 301 to 310 of about 2,159,893 (336)

Long-term oral glucocerebrosidase activator reduces soluble α-synuclein oligomer accumulation in Parkinsonian LRRK2 mutant mouse brain. [PDF]

NPJ Parkinsons Dis
Choi ZY, Liu H, Chang EE, Pang SY, Luo IL, Ruan Y, Wang Q, Malki Y, Zhang SX, Weng KY, Lau BW, Ng RC, Zhang Z, Ho SL, Ho PW.   +14 more
europepmc   +1 more source

Efficacy of Neratinib-Based Therapy in ERBB2-Mutant Lung Adenocarcinomas: Findings From 2 International Phase 2 Studies

Bob T. Li, Leena Gandhi, Vignesh Ravichandran, Benjamin Besse, Julien Mazières, Geoffrey I. Shapiro, Valentina Boni, Saiama N. Waqar, Haeseong Park, David I. Quinn, Alejandro Martínez, Salomon M. Stemmer, Alexis B. Cortot, Fabrice Barlési, Élisabeth Quoix, Mark E. Burkard, S. Duygu Selçuklu, C. Anthony Hunt, Mark T.A. Donoghue, Mark G. Kris, Judith D. Bebchuk, Lisa D. Eli, Leanne McCulloch, David B. Solit, Pasi A. Jänne   +24 more
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Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas. [PDF]

Acta Neuropathol
Hinz FE, Friedel D, Ippen FM, Sill M, Korshunov A, Schweizer L, Schrimpf D, Göbel K, Friedrich LS, Aras FK, Bogumil H, Banan R, Dohmen H, Acker T, Brandner S, Schmid S, Capper D, Grassl N, Boldt HB, Wesseling P, Maas SLN, Martinez JPG, Stadelmann C, Reifenberger G, Stehle T, Barrantes-Freer A, Juratli TA, Pusch S, Haag D, Reuss DE, Herold-Mende C, Krieg S, Wick W, Etminan N, Platten M, Pfister SM, Jones DTW, Sahm F, von Deimling A, Suwala AK.   +39 more
europepmc   +1 more source

A novel mouse cell line model reveals the tumor intrinsic and immune characteristics of EGFR-mutant lung cancer. [PDF]

Theranostics
Yan Y, Shang J, Liu C, Chen Y, Bao Y, Zhao Y, Fan F, Sun Y, Zhou Y, Wu Y, Wang Y, Han H, Chen H, Pan Y.   +13 more
europepmc   +1 more source

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Mutant

Proceedings of the ACM Symposium on Cloud Computing, 2018
Today's cloud database systems are not designed for seamless cost-performance trade-offs for changing SLOs. Database engineers have a limited number of trade-offs due to the limited storage types offered by cloud vendors, and switching to a different storage type requires a time-consuming data migration to a new database.
Hobin Yoon, Juncheng Yang, Sveinn Fannar Kristjansson, Steinn E. Sigurdarson, Ymir Vigfusson, Ada Gavrilovska   +5 more
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Microtubule mutants

Canadian Journal of Biochemistry and Cell Biology, 1985
Genetics has become an important tool for studying microtubule structure and function. Mutations in genes that encode microtubule proteins have been isolated in several, evolutionarily diverse organisms. These mutations have been, and will increasingly be, of great value in determining which cellular events are microtubule mediated, in determining ...
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Targeting mutant KRAS

Current Opinion in Chemical Biology, 2021
The protein KRAS has for decades been considered a holy grail of cancer drug discovery. For most of that time, it has also been considered undruggable. Since 2018, five compounds have entered the clinic targeting a single mutant form of KRAS, G12C. Here, we review each of these compounds along with additional approaches to targeting this and other ...
Daniel A, Erlanson, Kevin R, Webster
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Mutant Proteogenomics

2016
Identification of mutant proteins in biological samples is one of the emerging areas of proteogenomics. Despite the fact that only a limited number of studies have been published up to now, it has the potential to recognize novel disease biomarkers that have unique structure and desirably high specificity.
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Reducing Mutants with Mutant Killable Precondition

2017 IEEE International Conference on Software Testing, Verification and Validation Workshops (ICSTW), 2017
Mutation analysis is a method for predicting the quality of test suite accurately. However, it has high computational cost due to the number of mutants that are generated. For example, the ROR (Relational Operator Replacement) mutation operator will generate seven mutants for just one relational operator.
Chihiro Iida, Shingo Takada
openaire   +1 more source