Results 341 to 350 of about 2,913,254 (384)
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Proceedings of the ACM Symposium on Cloud Computing, 2018
Today's cloud database systems are not designed for seamless cost-performance trade-offs for changing SLOs. Database engineers have a limited number of trade-offs due to the limited storage types offered by cloud vendors, and switching to a different storage type requires a time-consuming data migration to a new database.
Hobin Yoon +5 more
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Today's cloud database systems are not designed for seamless cost-performance trade-offs for changing SLOs. Database engineers have a limited number of trade-offs due to the limited storage types offered by cloud vendors, and switching to a different storage type requires a time-consuming data migration to a new database.
Hobin Yoon +5 more
openaire +1 more source
Canadian Journal of Biochemistry and Cell Biology, 1985
Genetics has become an important tool for studying microtubule structure and function. Mutations in genes that encode microtubule proteins have been isolated in several, evolutionarily diverse organisms. These mutations have been, and will increasingly be, of great value in determining which cellular events are microtubule mediated, in determining ...
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Genetics has become an important tool for studying microtubule structure and function. Mutations in genes that encode microtubule proteins have been isolated in several, evolutionarily diverse organisms. These mutations have been, and will increasingly be, of great value in determining which cellular events are microtubule mediated, in determining ...
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Current Opinion in Chemical Biology, 2021
The protein KRAS has for decades been considered a holy grail of cancer drug discovery. For most of that time, it has also been considered undruggable. Since 2018, five compounds have entered the clinic targeting a single mutant form of KRAS, G12C. Here, we review each of these compounds along with additional approaches to targeting this and other ...
Daniel A, Erlanson, Kevin R, Webster
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The protein KRAS has for decades been considered a holy grail of cancer drug discovery. For most of that time, it has also been considered undruggable. Since 2018, five compounds have entered the clinic targeting a single mutant form of KRAS, G12C. Here, we review each of these compounds along with additional approaches to targeting this and other ...
Daniel A, Erlanson, Kevin R, Webster
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2016
Identification of mutant proteins in biological samples is one of the emerging areas of proteogenomics. Despite the fact that only a limited number of studies have been published up to now, it has the potential to recognize novel disease biomarkers that have unique structure and desirably high specificity.
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Identification of mutant proteins in biological samples is one of the emerging areas of proteogenomics. Despite the fact that only a limited number of studies have been published up to now, it has the potential to recognize novel disease biomarkers that have unique structure and desirably high specificity.
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Reducing Mutants with Mutant Killable Precondition
2017 IEEE International Conference on Software Testing, Verification and Validation Workshops (ICSTW), 2017Mutation analysis is a method for predicting the quality of test suite accurately. However, it has high computational cost due to the number of mutants that are generated. For example, the ROR (Relational Operator Replacement) mutation operator will generate seven mutants for just one relational operator.
Chihiro Iida, Shingo Takada
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Trends in Genetics, 1988
Abstract Many of the basic facts about plant hormones are still obscure, including biosynthetic pathways and their regulation. Furthermore, our knowledge of the molecular steps between hormones and their action is extremely limited. The increasing collection of isogenic genotypes differing in hormone synthesis or responses offers great promise for ...
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Abstract Many of the basic facts about plant hormones are still obscure, including biosynthetic pathways and their regulation. Furthermore, our knowledge of the molecular steps between hormones and their action is extremely limited. The increasing collection of isogenic genotypes differing in hormone synthesis or responses offers great promise for ...
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Haemagglutinin transport mutants
Vaccine, 1985Two mutants (ts1 and ts651) with a temperature sensitive defect in the intracellular transport of the haemagglutinin from the rough endoplasmic reticulum to the plasma membrane have been analysed. Nucleotide sequencing of the haemagglutinin revealed with each mutant two point mutations that are located in the stem region of the molecule.
W, Garten +5 more
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Nature, 1976
WE report here a new maternal effect mutation (nc, for no cleavage) in the Mexican axolotl, Ambystoma mexicanum. This mutation involves a defect in the assembly of microtubules in the fertilised egg. There is a large literature describing the molecular and biochemical events which accompany the in vitro self-assembly of microtubules; the nc mutant is ...
E C, Raff, A J, Brothers, R A, Raff
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WE report here a new maternal effect mutation (nc, for no cleavage) in the Mexican axolotl, Ambystoma mexicanum. This mutation involves a defect in the assembly of microtubules in the fertilised egg. There is a large literature describing the molecular and biochemical events which accompany the in vitro self-assembly of microtubules; the nc mutant is ...
E C, Raff, A J, Brothers, R A, Raff
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Trends in Genetics, 2001
Mitochondrial DNA (mtDNA) encodes a mere 13 polypeptides, all with well-defined cellular functions in mitochondrial energy metabolism. It was first sequenced over two decades ago, yet our understanding of the wider physiological role of mtDNA is surprisingly sketchy.
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Mitochondrial DNA (mtDNA) encodes a mere 13 polypeptides, all with well-defined cellular functions in mitochondrial energy metabolism. It was first sequenced over two decades ago, yet our understanding of the wider physiological role of mtDNA is surprisingly sketchy.
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1994
Publisher Summary This chapter describes the modifications to the plaque assay that is developed for use with the facultative intracellular bacterial pathogen Listeria monocytogenes and how this assay is used to isolate mutants defective in intracellular growth and cell-to-cell spread. The technique can be used to screen populations of mutants or can
S, Jones, D A, Portnoy
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Publisher Summary This chapter describes the modifications to the plaque assay that is developed for use with the facultative intracellular bacterial pathogen Listeria monocytogenes and how this assay is used to isolate mutants defective in intracellular growth and cell-to-cell spread. The technique can be used to screen populations of mutants or can
S, Jones, D A, Portnoy
openaire +2 more sources