Results 101 to 110 of about 8,186,126 (347)

In Silico Modeling of a Mutant Cas9 Protein for High-Fidelity Genome Editing [PDF]

مجله انفورماتیک سلامت و زیست پزشکی
Introduction: CRISPR/Cas system is a bacterial-acquired immune system against viruses. spCas9 protein-derived from Streptococcus pyogenes is the most common Cas protein used in genome editing. The Cas9 proteins suffer from some problems like unwanted off-
Mahsa Ghasemi, Javad Zamani, Zarrin Minuchehr, Mehdi Shamsara   +3 more
doaj  

Selective processing and metabolism of disease-causing mutant prion proteins. [PDF]

PLoS Pathogens, 2009
Prion diseases are fatal neurodegenerative disorders caused by aberrant metabolism of the cellular prion protein (PrP(C)). In genetic forms of these diseases, mutations in the globular C-terminal domain are hypothesized to favor the spontaneous ...
Aarthi Ashok, Ramanujan S Hegde
doaj   +1 more source

Conserved Residues R420 and Q428 in a Cytoplasmic Loop of the Citrate/Malate Transporter CimH of Bacillus subtilis Are Accessible from the External Face of the Membrane [PDF]

, 2003
CimH of Bacillus subtilis is a secondary transporter for citrate and malate that belongs to the 2-hydroxycarboxylate transporter (2HCT) family. Conserved residues R143, R420, and Q428, located in putative cytoplasmic loops and R432, located at the ...
Krom, Bastiaan P.,, Lolkema, Juke S.,
core   +2 more sources

Mutant p53 in Cancer Progression and Targeted Therapies

Frontiers in Oncology, 2020
TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority of mutations of p53 are missense mutations, leading to the expression of the full length p53 mutant proteins. Mutant p53 (Mutp53) proteins not only lose wild-type p53-
Gao‑Chun Zhu, Chaoyun Pan, J. Bei, Bo Li, Chen Liang, Yang Xu, Xuemei Fu   +6 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Extracellular Matrix Disparities in an Nkx2-5 Mutant Mouse Model of Congenital Heart Disease

Frontiers in Cardiovascular Medicine, 2020
Congenital heart disease (CHD) affects almost one percent of all live births. Despite diagnostic and surgical reparative advances, the causes and mechanisms of CHD are still primarily unknown.
Deanna Bousalis, Christopher S. Lacko, Nora Hlavac, Fariz Alkassis, Rebecca A. Wachs, Sahba Mobini, Sahba Mobini, Christine E. Schmidt, Hideko Kasahara   +8 more
doaj   +1 more source

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

Journal of Biological Chemistry, 2010
Many of the neurodegenerative diseases that afflict people are caused by intracytoplasmic aggregate-prone proteins. These include Parkinson disease, tauopathies, and polyglutamine expansion diseases such as Huntington disease. In Mendelian forms of these
Maurizio Renna, M. Jimenez-Sanchez, Sovan Sarkar, D. Rubinsztein   +3 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Mutant p53: multiple mechanisms define biologic activity in cancer

Frontiers in Oncology, 2015
The functional importance of p53 as a tumor suppressor gene is evident through its pervasiveness in cancer biology. The p53 gene is the most commonly altered gene in human cancer; however, not all genetic alterations are biologically equivalent.
Michael Paul Kim, Michael Paul Kim, Yun eZhang, Guillermina eLozano   +3 more
doaj   +1 more source

Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins [PDF]

, 1989
Four complementation groups of temperature-sensitive (ts) mutants of Sindbis virus that fail to make RNA at the nonpermissive temperature are known, and we have previously shown that group F mutants have defects in nsP4.
Hahn, Young S., Strauss, Ellen G., Strauss, James H.   +2 more
core   +1 more source