Results 181 to 190 of about 6,880,999 (291)

Mutant proteins as cancer-specific biomarkers

Proceedings of the National Academy of Sciences of the United States of America, 2011
Qing Wang, Raghothama Chaerkady, Jian Wu, Heejung Hwang, N. Papadopoulos, L. Kopelovich, A. Maitra, H. Matthaei, J. Eshleman, R. Hruban, K. Kinzler, A. Pandey, B. Vogelstein   +12 more
semanticscholar   +1 more source

Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin.

, 1988
Jean‐Paul Boissel, TJ Kasper, H. Franklin Bunn   +2 more
openalex   +1 more source

Computational Study of Assembly and Toxicity Inhibition of Amyloid Beta-Protein and Its Arctic Mutant [PDF]

, 2009
Brigita Urbanc, Gal Bitan, Luis Cruz, Alfonso Lam, David B. Teplow   +4 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring. [PDF]

PLoS One, 2018
Kondratick CM, Litman JM, Shaffer KV, Washington MT, Dieckman LM.   +4 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

EMBO Reports, 2015
Silvia Di Agostino, G. Sorrentino, Eleonora Ingallina, F. Valenti, M. Ferraiuolo, S. Bicciato, Silvano Piazza, S. Strano, G. Del Sal, G. Blandino   +9 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The localization of protein L19 on the surface of 50 S subunits of Escherichia coli aided by the use of mutants lacking protein L19.

, 1984
Georg Stöffler, M Noah, Marina Stöffler-Meilicke, Eric R. Dabbs   +3 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source