Results 11 to 20 of about 1,312,216 (336)

Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice

Vaccines, 2021
Multiple variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have spread around the world, but the neutralizing effects of antibodies induced by the existing vaccines have declined, which highlights the importance of developing ...
Juan Shi, Xiaoxiao Jin, Yan Ding, Xiaotao Liu, Anran Shen, Yandan Wu, Min Peng, Chuanlai Shen   +7 more
doaj   +1 more source

Mapping and Characterization of the fefe Gene That Controls Iron Uptake in Melon (Cucumis melo L.)

Frontiers in Plant Science, 2017
Iron (Fe) deficiency in plants limits crop growth and productivity. Molecular mechanisms that plants use to sense and respond to Fe deficiency by coordinated expression of Fe-uptake genes are not fully understood.
Raghuprakash Kastoori Ramamurthy, Brian M. Waters   +1 more
doaj   +1 more source

Comparative Physiological, Biochemical, and Proteomic Responses of Photooxidation-Prone Rice Mutant 812HS under High Light Conditions

Agronomy, 2021
Photosynthetic efficiency decreases as light energy surpasses the photosynthesis capacity. This study was designed to investigate the potential effects of high-intensity light on the photooxidation-prone mutant 812HS of rice and its wild-type 812S during
Aisha Almakas, Guoxiang Chen, Fahad Masoud Wattoo, Rashid Mehmood Rana, Muhammad Asif Saleem, Zhiping Gao, Muhammad Waqas Amjid, Muhammad Ishaq Asif Rehmani, Abeer Hashem, Elsayed Fathi Abd_Allah   +9 more
doaj   +1 more source

Mutant proteins as cancer-specific biomarkers [PDF]

Proceedings of the National Academy of Sciences, 2011
Cancer biomarkers are currently the subject of intense research because of their potential utility for diagnosis, prognosis, and targeted therapy. In theory, the gene products resulting from somatic mutations are the ultimate protein biomarkers, being not simply associated with tumors but actually responsible for tumorigenesis.
Qing, Wang, Raghothama, Chaerkady, Jian, Wu, Hee Jung, Hwang, Nick, Papadopoulos, Levy, Kopelovich, Anirban, Maitra, Hanno, Matthaei, James R, Eshleman, Ralph H, Hruban, Kenneth W, Kinzler, Akhilesh, Pandey, Bert, Vogelstein   +12 more
openaire   +2 more sources

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials [PDF]

, 2006
Recent studies suggest that the toxicity of familial amyotrophic lateral sclerosis mutant Cu, Zn superoxide dismutase (SOD1) arises from its selective recruitment to mitochondria. Here we demonstrate that each of 12 different familial ALS-mutant SOD1s
Butler Gralla, Edith, Carrì, Maria Teresa, Casciati, Arianna, Cozzolino, Mauro, Crosio, Claudia, Ferri, Alberto, Nencini, Monica, Rotilio, Giuseppe, Valentine, Joan Selverstone   +8 more
core   +2 more sources

ruvA Mutants that resolve Holliday junctions but do not reverse replication forks [PDF]

, 2008
RuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by replication fork reversal, a reaction which ...
A Blastyak, A Constantinou, A Kuzminov, A Machwe, Alison Sylvia Bradley, B Guenther, B Michel, B Michel, Bénédicte Michel, C Ralf, CA Parsons, CE Shurvinton, CV Privezentzev, CZ Bachrati, D Chamberlain, D Hargreaves, DV Bugreev, EC Friedberg, EP Rocha, F Lecointe, F Osman, F Osman, G Grompone, H Iwasaki, H Shinagawa, IR Tsaneva, IR Tsaneva, Irina Tsaneva, JB Rafferty, JH Miller, JK Karow, JR Donaldson, K Hiom, K Yamada, K Yamada, L Wu, M Ariyoshi, M Fromant, M Lopes, M Oram, M Seigneur, Marie Le Masson, MC Whitby, MC Whitby, ME Robu, MJ Flores, P McGlynn, P McGlynn, P McGlynn, P McGlynn, R Lestini, RC Heller, RG Lloyd, SC West, SD Vincent, SM Roe, SN Chan, T Hishida, T Hishida, T Nishino, T Nishino, T Shibata, TN Mandal, W Bussen, William F. Burkholder, Y Liu, Y Liu, Z Baharoglu, Zeynep Baharoglu   +68 more
core   +9 more sources

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]

, 1994
The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
Harkness, Troy A. A., Klei, Ida J. van der, Lill, Roland, Nargang, Frank E., Neupert, Walter   +4 more
core   +8 more sources

Effects of g.10329C>T polymorphism in the SCD gene with milk production traits in Bangladeshi cattle: evidence from mutant protein function analysis [PDF]

Journal of Central European Agriculture
This study aimed to pinpoint the single nucleotide polymorphisms (SNPs) within the stearoyl-CoA desaturase (SCD) gene that is notably linked to milk production traits and to evaluate the structural and functional consequences of mutant proteins.
Md Abdul Alim, Mridha Mohammad Kamal HOSSAIN, Nusrat JAHAN, Rubaya RUBAYA, Anjuman Ara BHUYAN, Jahangir ALAM, Ishtiaque AHAMMAD, Arittra BHATTACHARJEE, Mohammad Shohel Rana SIDDIKI, Md MONIRUZZAMAN   +9 more
doaj   +1 more source

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Advanced Science, 2023
Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be ...
Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li   +16 more
doaj   +1 more source

Overlapping functionality of the Pht proteins in zinc homeostasis of streptococcus pneumoniae [PDF]

, 2014
Streptococcus pneumoniae is a globally significant pathogen that causes a range of diseases, including pneumonia, sepsis, meningitis, and otitis media. Its ability to cause disease depends upon the acquisition of nutrients from its environment, including
Eijkelkamp, Bart A., Harvey, Richard M., Hughes, Catherine E., McDevitt, Christopher A., Paton, James C., Plumptre, Charles D.   +5 more
core   +1 more source