Results 11 to 20 of about 6,880,999 (291)

A new platform host for strong expression under GAL promoters without inducer in Saccharomyces cerevisiae

Biotechnology Reports, 2022
The gal80 mutant of yeast Saccharomyces cerevisiae is used for the constitutive expression under strong GAL promoters without galactose induction. To enhance productivity of gal80 mutant, an alternative strain, allgal, was developed by removing all ...
Mi-Jin Kim, Bong Hyun Sung, Hyun-Joo Park, Jung-Hoon Sohn, Jung-Hoon Bae   +4 more
doaj   +1 more source

Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation. [PDF]

PLoS ONE, 2013
Leishmania cysteine proteases are potential vaccine candidates and drug targets. To study the role of cathepsin B cysteine protease, we have generated and characterized cathepsin B null mutant L. donovani parasites. L.
Teklu Kuru Gerbaba, Lashitew Gedamu
doaj   +1 more source

The Infantile Leukoencephalopathy-Associated Mutation of C11ORF73/HIKESHI Proteins Generates De Novo Interactive Activity with Filamin A, Inhibiting Oligodendroglial Cell Morphological Differentiation

Medicines, 2021
Background: Genetic hypomyelinating diseases are a heterogeneous group of disorders involving the white matter. One infantile hypomyelinating leukoencephalopathy is associated with the homozygous variant (Cys4-to-Ser (C4S)) of the c11orf73 gene. Methods:
Kohei Hattori, Kenji Tago, Shiori Memezawa, Arisa Ochiai, Sui Sawaguchi, Yukino Kato, Takanari Sato, Kazuma Tomizuka, Hiroaki Ooizumi, Katsuya Ohbuchi, Kazushige Mizoguchi, Yuki Miyamoto, Junji Yamauchi   +12 more
doaj   +1 more source

Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum. [PDF]

PLoS ONE, 2012
Long QT syndrome type 2 (LQT2) is the second most common type of all long QT syndromes. It is well-known that trafficking deficient mutant human ether-a-go-go-related gene (hERG) proteins are often involved in LQT2.
Ying Wang, Xiaoyan Huang, Jianqing Zhou, Xi Yang, Di Li, Haiyan Mao, Huan Huan Sun, Ningsheng Liu, Jiangfang Lian   +8 more
doaj   +1 more source

Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice

Vaccines, 2021
Multiple variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have spread around the world, but the neutralizing effects of antibodies induced by the existing vaccines have declined, which highlights the importance of developing ...
Juan Shi, Xiaoxiao Jin, Yan Ding, Xiaotao Liu, Anran Shen, Yandan Wu, Min Peng, Chuanlai Shen   +7 more
doaj   +1 more source

Mapping and Characterization of the fefe Gene That Controls Iron Uptake in Melon (Cucumis melo L.)

Frontiers in Plant Science, 2017
Iron (Fe) deficiency in plants limits crop growth and productivity. Molecular mechanisms that plants use to sense and respond to Fe deficiency by coordinated expression of Fe-uptake genes are not fully understood.
Raghuprakash Kastoori Ramamurthy, Brian M. Waters   +1 more
doaj   +1 more source

Comparative Physiological, Biochemical, and Proteomic Responses of Photooxidation-Prone Rice Mutant 812HS under High Light Conditions

Agronomy, 2021
Photosynthetic efficiency decreases as light energy surpasses the photosynthesis capacity. This study was designed to investigate the potential effects of high-intensity light on the photooxidation-prone mutant 812HS of rice and its wild-type 812S during
Aisha Almakas, Guoxiang Chen, Fahad Masoud Wattoo, Rashid Mehmood Rana, Muhammad Asif Saleem, Zhiping Gao, Muhammad Waqas Amjid, Muhammad Ishaq Asif Rehmani, Abeer Hashem, Elsayed Fathi Abd_Allah   +9 more
doaj   +1 more source

Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Journal of Hematology & Oncology, 2016
BackgroundSomatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways.
Lijuan Han, C. Schubert, J. Köhler, M. Schemionek, S. Isfort, T. Brümmendorf, S. Koschmieder, Nicolas Chatain   +7 more
semanticscholar   +1 more source

Effects of g.10329C>T polymorphism in the SCD gene with milk production traits in Bangladeshi cattle: evidence from mutant protein function analysis [PDF]

Journal of Central European Agriculture
This study aimed to pinpoint the single nucleotide polymorphisms (SNPs) within the stearoyl-CoA desaturase (SCD) gene that is notably linked to milk production traits and to evaluate the structural and functional consequences of mutant proteins.
Md Abdul Alim, Mridha Mohammad Kamal HOSSAIN, Nusrat JAHAN, Rubaya RUBAYA, Anjuman Ara BHUYAN, Jahangir ALAM, Ishtiaque AHAMMAD, Arittra BHATTACHARJEE, Mohammad Shohel Rana SIDDIKI, Md MONIRUZZAMAN   +9 more
doaj   +1 more source

Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations

Journal of Clinical Endocrinology and Metabolism, 2016
Context: The pathogenic effect of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene (AIPmuts) in pituitary adenomas is incompletely understood.
L. Hernández-Ramírez, F. Martucci, R. Morgan, G. Trivellin, Daniel Tilley, Nancy Ramos-Guajardo, D. Iacovazzo, F. D’Acquisto, C. Prodromou, M. Korbonits   +9 more
semanticscholar   +1 more source