Results 191 to 200 of about 1,312,216 (336)

Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation. [PDF]

Sci Rep, 2019
Hoch L, Henriques SF, Bruge C, Marsolier J, Benabides M, Bourg N, Tournois J, Mahé G, Morizur L, Jarrige M, Bigot A, Richard I, Nissan X.   +12 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Impact of HLD6-associated TUBB4A mutant proteins on cell morphogenesis. [PDF]

BMC Res Notes
Kasamatsu Y, Tanaka M, Minegishi M, Miyamoto Y, Yamauchi J.   +4 more
europepmc   +1 more source

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers. [PDF]

Elife, 2018
Fang D, Gan H, Cheng L, Lee JH, Zhou H, Sarkaria JN, Daniels DJ, Zhang Z.   +7 more
europepmc   +1 more source

A mutant of the phototoxic protein KillerRed that does not form DsRed-like chromophore [PDF]

, 2019
D.A. Gorbachev, Karen S. Sarkisyan
openalex   +1 more source

Mutant Protein Constructs

Production of mutant protein ...
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation. [PDF]

Commun Biol
Rahman A, Tamseel S, Dutta S, Khan N, Faaiz M, Rastogi H, Nath JR, Haldar K, Chowdhury P, Ashish, Bhattacharjee S.   +10 more
europepmc   +1 more source

Kasembeli MM, Kaparos E, Bharadwaj U, et al. Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers. Blood. 2023;141(12):1411-1424.

Blood, 2023
europepmc   +1 more source

The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies. [PDF]

Int J Mol Sci, 2018
Borovikov YS, Karpicheva OE, Simonyan AO, Avrova SV, Rogozovets EA, Sirenko VV, Redwood CS.   +6 more
europepmc   +1 more source