Results 21 to 30 of about 8,186,126 (347)

Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice

Vaccines, 2021
Multiple variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have spread around the world, but the neutralizing effects of antibodies induced by the existing vaccines have declined, which highlights the importance of developing ...
Juan Shi, Xiaoxiao Jin, Yan Ding, Xiaotao Liu, Anran Shen, Yandan Wu, Min Peng, Chuanlai Shen   +7 more
doaj   +1 more source

Mapping and Characterization of the fefe Gene That Controls Iron Uptake in Melon (Cucumis melo L.)

Frontiers in Plant Science, 2017
Iron (Fe) deficiency in plants limits crop growth and productivity. Molecular mechanisms that plants use to sense and respond to Fe deficiency by coordinated expression of Fe-uptake genes are not fully understood.
Raghuprakash Kastoori Ramamurthy, Brian M. Waters   +1 more
doaj   +1 more source

Overlapping functionality of the Pht proteins in zinc homeostasis of streptococcus pneumoniae [PDF]

, 2014
Streptococcus pneumoniae is a globally significant pathogen that causes a range of diseases, including pneumonia, sepsis, meningitis, and otitis media. Its ability to cause disease depends upon the acquisition of nutrients from its environment, including
Eijkelkamp, Bart A., Harvey, Richard M., Hughes, Catherine E., McDevitt, Christopher A., Paton, James C., Plumptre, Charles D.   +5 more
core   +1 more source

Effects of g.10329C>T polymorphism in the SCD gene with milk production traits in Bangladeshi cattle: evidence from mutant protein function analysis [PDF]

Journal of Central European Agriculture
This study aimed to pinpoint the single nucleotide polymorphisms (SNPs) within the stearoyl-CoA desaturase (SCD) gene that is notably linked to milk production traits and to evaluate the structural and functional consequences of mutant proteins.
Md Abdul Alim, Mridha Mohammad Kamal HOSSAIN, Nusrat JAHAN, Rubaya RUBAYA, Anjuman Ara BHUYAN, Jahangir ALAM, Ishtiaque AHAMMAD, Arittra BHATTACHARJEE, Mohammad Shohel Rana SIDDIKI, Md MONIRUZZAMAN   +9 more
doaj   +1 more source

Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]

, 2018
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M., Gilk, Stacey D., Justis, Anna V., Mulye, Minal, Nallandhighal, Srinivas, Tran, Tuan M.   +5 more
core   +1 more source

Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Journal of Hematology & Oncology, 2016
BackgroundSomatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways.
Lijuan Han, C. Schubert, J. Köhler, M. Schemionek, S. Isfort, T. Brümmendorf, S. Koschmieder, Nicolas Chatain   +7 more
semanticscholar   +1 more source

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Advanced Science, 2023
Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be ...
Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li   +16 more
doaj   +1 more source

Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations

Journal of Clinical Endocrinology and Metabolism, 2016
Context: The pathogenic effect of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene (AIPmuts) in pituitary adenomas is incompletely understood.
L. Hernández-Ramírez, F. Martucci, R. Morgan, G. Trivellin, Daniel Tilley, Nancy Ramos-Guajardo, D. Iacovazzo, F. D’Acquisto, C. Prodromou, M. Korbonits   +9 more
semanticscholar   +1 more source

A GMC Oxidoreductase GmcA Is Required for Symbiotic Nitrogen Fixation in Rhizobium leguminosarum bv. viciae

Frontiers in Microbiology, 2020
GmcA is a FAD-containing enzyme belonging to the GMC (glucose-methanol-choline oxidase) family of oxidoreductases. A mutation in the Rhizobium leguminosarum gmcA gene was generated by homologous recombination.
Qian Zou, Sha Luo, Hetao Wu, Donglan He, Xiaohua Li, Guojun Cheng   +5 more
doaj   +1 more source

Knock-Out of the Genes Coding for the Rieske Protein and the ATP-Synthase δ-Subunit of Arabidopsis [PDF]

, 2003
In Arabidopsis, the nuclear genes PetC and AtpD code for the Rieske protein of the cytochrome b6/f (cyt b6/f) complex and the δ-subunit of the chloroplast ATP synthase (cpATPase), respectively.
Dietzmann, Angela, Jahns, Peter, Joliot, Anne, Joliot, Pierre, Leister, Dario, Levin, Joshua Z., Maiwald, Daniela, Pesaresi, Paolo, Salamini, Francesco   +8 more
core   +1 more source