Results 21 to 30 of about 6,880,999 (291)

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Advanced Science, 2023
Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be ...
Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li   +16 more
doaj   +1 more source

Thermodynamics of protein denaturation at temperatures over 100 °C: CutA1 mutant proteins substituted with hydrophobic and charged residues

Scientific Reports, 2015
Although the thermodynamics of protein denaturation at temperatures over 100 °C is essential for the rational design of highly stable proteins, it is not understood well because of the associated technical difficulties.
Y. Matsuura, Michiyo Takehira, Y. Joti, K. Ogasahara, Tomoyuki Tanaka, N. Ono, N. Kunishima, K. Yutani   +7 more
semanticscholar   +1 more source

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders*

Journal of Biological Chemistry, 2015
Background: 20 read-through mutations that produce C-terminally extended proteins are related to human hereditary disorders. Results: The C-terminal extended proteins of mouse cFLIP-L (cellular FLICE-like apoptosisinhibitory protein) and human PNPO ...
N. Shibata, Nobumichi Ohoka, Yusuke Sugaki, Chiaki Onodera, Mizuho Inoue, Y. Sakuraba, Daisuke Takakura, N. Hashii, N. Kawasaki, Y. Gondo, M. Naito   +10 more
semanticscholar   +1 more source

Mutant p53 : One, No One and One Hundred Thousand

Frontiers in Oncology, 2015
Encoded by the mutated variants of the TP53 tumor suppressor gene, mutant p53 proteins are getting an increased experimental support as active oncoproteins promoting tumor growth and metastasis.
Dawid eWalerych, Kamil eLisek, Kamil eLisek, Giannino eDel Sal, Giannino eDel Sal   +4 more
doaj   +1 more source

A GMC Oxidoreductase GmcA Is Required for Symbiotic Nitrogen Fixation in Rhizobium leguminosarum bv. viciae

Frontiers in Microbiology, 2020
GmcA is a FAD-containing enzyme belonging to the GMC (glucose-methanol-choline oxidase) family of oxidoreductases. A mutation in the Rhizobium leguminosarum gmcA gene was generated by homologous recombination.
Qian Zou, Sha Luo, Hetao Wu, Donglan He, Xiaohua Li, Guojun Cheng   +5 more
doaj   +1 more source

Transcriptome analysis of the epidermis of the purple quail-like (q-lp) mutant of silkworm, Bombyx mori. [PDF]

PLoS ONE, 2017
A new purple quail-like (q-lp) mutant found from the plain silkworm strain 932VR has pigment dots on the epidermis similar to the pigment mutant quail (q).
Pingyang Wang, Zhiyong Qiu, Dingguo Xia, Shunming Tang, Xingjia Shen, Qiaoling Zhao   +5 more
doaj   +1 more source

JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity. [PDF]

PLoS ONE, 2010
The human polyomavirus, JC virus (JCV) produces five tumor proteins encoded by transcripts alternatively spliced from one precursor messenger RNA. Significant attention has been given to replication and transforming activities of JCV's large tumor ...
Brigitte Bollag, Catherine A Hofstetter, Marta M Reviriego-Mendoza, Richard J Frisque   +3 more
doaj   +1 more source

Anti-Tumor Effect of Turandot Proteins Induced via the JAK/STAT Pathway in the mxc Hematopoietic Tumor Mutant in Drosophila

Cells, 2023
Several antimicrobial peptides suppress the growth of lymph gland (LG) tumors in Drosophila multi sex comb (mxc) mutant larvae. The activity of another family of polypeptides, called Turandots, is also induced via the JAK/STAT pathway after bacterial ...
Yuriko Kinoshita, Naoka Shiratsuchi, Mayo Araki, Yoshihiro H. Inoue   +3 more
doaj   +1 more source

PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases

Neurobiology of Disease, 2003
In polyglutamine diseases, accumulation in the nucleus of mutant proteins induces the formation of neuronal intranuclear inclusions (NIIs). The nucleus is compartmentalized into structural and functional domains, which are involved in NII formation ...
Junko Takahashi, Hiroto Fujigasaki, Kiyoshi Iwabuchi, Amalia C Bruni, Toshiki Uchihara, Khalid H El Hachimi, Giovanni Stevanin, Alexandra Dürr, Anne-Sophie Lebre, Yvon Trottier, Hugues de Thé, Junichi Tanaka, Jean-Jacques Hauw, Charles Duyckaerts, Alexis Brice   +14 more
doaj   +1 more source

Substrate Protein Interactions and Methylglyoxal Modifications Reduce the Aggregation Propensity of Human Alpha-A-Crystallin G98R Mutant

Frontiers in Molecular Biosciences, 2022
The G98R mutation in αA-crystallin is associated with presenile cataract development in humans. Previous studies have indicated that mutant proteins altered structure, decreased stability, increased oligomeric size, loss of chaperone-like activity, and ...
Puttur Santhoshkumar, Krishna K. Sharma, Krishna K. Sharma   +2 more
doaj   +1 more source