Results 301 to 310 of about 1,312,216 (336)

Hydrogen-deuterium exchange reveals catalytically linked protein flexibility in myoglobin-mediated intramolecular C(sp³)-H activation. [PDF]

Protein Sci
Gao H, Camargo EA, Ubi JN, Duan X, Tian X, Deng H, Zheng G, Gao S.   +7 more
europepmc   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Pandora's Box of AML: How <i>TP53</i> Mutations Defy Therapy and Hint at New Hope. [PDF]

Biomedicines
Olesinski EA, Bhatt S.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Rebalancing the seed proteome following deletion of vicilin-related genes in pea (Pisum sativum L.). [PDF]

J Exp Bot
Rayner T, Saalbach G, Vickers M, Paajanen P, Martins C, Wouters RHM, Chinoy C, Mulholland F, Bal M, Isaac P, Novak P, Macas J, Ellis N, Steuernagel B, Domoney C.   +14 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Proteasomal Degradation of Mutant Huntingtin Exon1 Regulates Autophagy. [PDF]

Cells
Folger A, Chen C, Gonzalez P, Owutey SL, Wang Y.   +4 more
europepmc   +1 more source

Dual Phosphorylation of Thr175 and Ser176 Is Essential for SnRK1α1 Activation. [PDF]

Physiol Plant
Ávila A, López A, Cervantes J, Rodríguez-Sotres R, Martínez-Barajas E, Coello P.   +5 more
europepmc   +1 more source

In silico functional, structural, and pathogenicity assessment of single nucleotide polymorphisms in the human SOX9 gene. [PDF]

Sci Rep
Shadhin MST, Mia MS, Das Topu TK, Tanmoy MSI, Aktar S, Sultana J, Hossen F, Pranto AR, Tahsin N, Shahir NF, Talukder MEK.   +10 more
europepmc   +1 more source

Mutation of a conserved anthranilate phosphoribosyltransferase active site residue supports tryptophan biosynthesis <i>in vivo</i>. [PDF]

MicroPubl Biol
Klepin S, Michalik B, Pillus L, Chik JK.
europepmc   +1 more source