Results 31 to 40 of about 1,312,216 (336)
JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity. [PDF]
PLoS ONE, 2010 The human polyomavirus, JC virus (JCV) produces five tumor proteins encoded by transcripts alternatively spliced from one precursor messenger RNA. Significant attention has been given to replication and transforming activities of JCV's large tumor ...
Brigitte Bollag +3 more
doaj +1 more source
Cells, 2023 Several antimicrobial peptides suppress the growth of lymph gland (LG) tumors in Drosophila multi sex comb (mxc) mutant larvae. The activity of another family of polypeptides, called Turandots, is also induced via the JAK/STAT pathway after bacterial ...
Yuriko Kinoshita +3 more
doaj +1 more source
Knock-Out of the Genes Coding for the Rieske Protein and the ATP-Synthase δ-Subunit of Arabidopsis [PDF]
, 2003 In Arabidopsis, the nuclear genes PetC and AtpD code for the Rieske protein of the cytochrome b6/f (cyt b6/f) complex and the δ-subunit of the chloroplast ATP synthase (cpATPase), respectively.
Dietzmann, Angela +8 more
core +1 more source
PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases
Neurobiology of Disease, 2003 In polyglutamine diseases, accumulation in the nucleus of mutant proteins induces the formation of neuronal intranuclear inclusions (NIIs). The nucleus is compartmentalized into structural and functional domains, which are involved in NII formation ...
Junko Takahashi +14 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 The G98R mutation in αA-crystallin is associated with presenile cataract development in humans. Previous studies have indicated that mutant proteins altered structure, decreased stability, increased oligomeric size, loss of chaperone-like activity, and ...
Puttur Santhoshkumar +2 more
doaj +1 more source
DCMP: database of cancer mutant protein domains [PDF]
Database, 2021 Abstract Protein domains are functional and structural units of proteins. They are responsible for a particular function that contributes to protein’s overall role. Because of this essential role, the majority of the genetic variants occur in the domains.
Isaac Arnold Emerson +1 more
openaire +2 more sources
In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa [PDF]
, 2015 The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required.
Bragonzi, Alessandra +5 more
core +1 more source
Neurobiology of Disease, 2013 Mutations in superoxide dismutase 1 (SOD1) are found in approximately 20% of patients with familial amyotrophic lateral sclerosis. The propensity of mutant SOD1 to form aggregates in pathologically affected cells (i.e. motor neurons) has implicated these
Terrell E. Brotherton +2 more
doaj +1 more source
PLoS ONE, 2020 Biallelic mutations in ACP5, encoding tartrate-resistant acid phosphatase (TRACP), have recently been identified to cause the inherited immuno-osseous disorder, spondyloenchondrodysplasia (SPENCD).
Janani Ramesh +8 more
doaj +1 more source
Nuclear Photosynthetic Gene Expression Is Synergistically Modulated by Rates of Protein Synthesis in Chloroplasts and Mitochondria [PDF]
, 2006 Arabidopsis thaliana mutants prors1-1 and -2 were identified on the basis of a decrease in effective photosystem II quantum yield. Mutations were localized to the 5'-untranslated region of the nuclear gene PROLYL-tRNA SYNTHETASE1 (PRORS1), which acts in ...
Bhushan, Shashi +7 more
core +2 more sources