Results 41 to 50 of about 8,186,126 (347)

Deficiency of RgpG causes major defects in cell division and biofilm formation, and deficiency of LytR-CpsAPsr family proteins leads to accumulation of cell wall antigens in culture medium by Streptococcus mutans [PDF]

, 2017
Streptococcus mutans is known to possess rhamnose-glucose polysaccharide (RGP), a major cell wall antigen. S. mutans strains deficient in rgpG , encoding the first enzyme of the RGP biosynthesis
Beatty, Wandy L, Bitoun, Jacob P, De, Arpan, Liao, Sumei, Roth, Randy, Wen, Zezhang T, Wu, Hui   +6 more
core   +2 more sources

Methionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities

PLoS Genetics, 2015
Although mistranslation is commonly believed to be deleterious, recent evidence indicates that mistranslation can be actively regulated and be beneficial in stress response.
Xiaoyun Wang, T. Pan
semanticscholar   +1 more source

PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases

Neurobiology of Disease, 2003
In polyglutamine diseases, accumulation in the nucleus of mutant proteins induces the formation of neuronal intranuclear inclusions (NIIs). The nucleus is compartmentalized into structural and functional domains, which are involved in NII formation ...
Junko Takahashi, Hiroto Fujigasaki, Kiyoshi Iwabuchi, Amalia C Bruni, Toshiki Uchihara, Khalid H El Hachimi, Giovanni Stevanin, Alexandra Dürr, Anne-Sophie Lebre, Yvon Trottier, Hugues de Thé, Junichi Tanaka, Jean-Jacques Hauw, Charles Duyckaerts, Alexis Brice   +14 more
doaj   +1 more source

Substrate Protein Interactions and Methylglyoxal Modifications Reduce the Aggregation Propensity of Human Alpha-A-Crystallin G98R Mutant

Frontiers in Molecular Biosciences, 2022
The G98R mutation in αA-crystallin is associated with presenile cataract development in humans. Previous studies have indicated that mutant proteins altered structure, decreased stability, increased oligomeric size, loss of chaperone-like activity, and ...
Puttur Santhoshkumar, Krishna K. Sharma, Krishna K. Sharma   +2 more
doaj   +1 more source

Morphological development and cytochrome c oxidase activity in Streptomyces lividans are dependent on the action of a copper bound Sco protein [PDF]

, 2013
Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics.
Calabrese L, Green GN, Holmgren A, Keijser BJ, Kieser TB, van Wezel GP   +5 more
core   +2 more sources

DCMP: database of cancer mutant protein domains [PDF]

Database, 2021
Abstract Protein domains are functional and structural units of proteins. They are responsible for a particular function that contributes to protein’s overall role. Because of this essential role, the majority of the genetic variants occur in the domains.
Isaac Arnold Emerson, Kiran Kumar Chitluri   +1 more
openaire   +2 more sources

Cellular toxicity of mutant SOD1 protein is linked to an easily soluble, non-aggregated form in vitro

Neurobiology of Disease, 2013
Mutations in superoxide dismutase 1 (SOD1) are found in approximately 20% of patients with familial amyotrophic lateral sclerosis. The propensity of mutant SOD1 to form aggregates in pathologically affected cells (i.e. motor neurons) has implicated these
Terrell E. Brotherton, Yingjie Li, Jonathan D. Glass   +2 more
doaj   +1 more source

Characterisation of ACP5 missense mutations encoding tartrate-resistant acid phosphatase associated with spondyloenchondrodysplasia.

PLoS ONE, 2020
Biallelic mutations in ACP5, encoding tartrate-resistant acid phosphatase (TRACP), have recently been identified to cause the inherited immuno-osseous disorder, spondyloenchondrodysplasia (SPENCD).
Janani Ramesh, Latha K Parthasarathy, Anthony J Janckila, Farhana Begum, Ramya Murugan, Balakumar P S S Murthy, Rif S El-Mallakh, Ranga N Parthasarathy, Bhuvarahamurthy Venugopal   +8 more
doaj   +1 more source

Small secreted proteins enable biofilm development in the cyanobacterium Synechococcus elongatus. [PDF]

, 2016
Small proteins characterized by a double-glycine (GG) secretion motif, typical of secreted bacterial antibiotics, are encoded by the genomes of diverse cyanobacteria, but their functions have not been investigated to date.
Golden, Susan, Nagar, Elad, Parnasa, Rami, Reich, Ziv, Schwarz, Rakefet, Sendersky, Eleonora, Simkovsky, Ryan   +6 more
core   +1 more source

Rare Neurologic Disease-Associated Mutations of AIMP1 Are Related with Inhibitory Neuronal Differentiation Which Is Reversed by Ibuprofen

Medicines, 2020
Background: Hypomyelinating leukodystrophy 3 (HLD3), previously characterized as a congenital diseases associated with oligodendrocyte myelination, is increasingly regarded as primarily affecting neuronal cells.
Yu Takeuchi, Marina Tanaka, Nanako Okura, Yasuyuki Fukui, Ko Noguchi, Yoshihiro Hayashi, Tomohiro Torii, Hiroaki Ooizumi, Katsuya Ohbuchi, Kazushige Mizoguchi, Yuki Miyamoto, Junji Yamauchi   +11 more
doaj   +1 more source