A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]
, 1994 The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
Harkness, Troy A. A. +4 more
core +8 more sources
Proteomic Analysis of the GacA Response Regulator in Pseudomonas chlororaphis O6
Research in Plant Disease, 2018 The GacS/GacA system in the root colonizer Pseudomonas chlororaphis O6 is a key regulatory system of many traits relevant to the plant probiotic nature of this bacterium.
Anne J. Anderson, Young Cheol Kim
doaj +1 more source
SUMO3 modification accelerates the aggregation of ALS-linked SOD1 mutants. [PDF]
PLoS ONE, 2014 Mutations in superoxide dismutase 1 (SOD1) are a major cause of familial amyotrophic lateral sclerosis (ALS), whereby the mutant proteins misfold and aggregate to form intracellular inclusions.
Takako Niikura +2 more
doaj +1 more source
Frontiers in Microbiology, 2022 Leptospirosis is a worldwide zoonosis caused by pathogenic species of the genus Leptospira. The recent application of CRISPR interference (CRISPRi) to Leptospira facilitates targeted gene silencing and provides a new tool to investigate pathogenic ...
Luis G. V. Fernandes +6 more
doaj +1 more source
Binding of small interfering RNA molecules is crucial for RNA interference suppressor activity of rice hoja blanca virus NS3 in plants [PDF]
, 2009 The NS3 protein of rice hoja blanca tenuivirus represents a viral suppressor of RNAi that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, an ...
Goldbach, R.W. +5 more
core +2 more sources
The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesis
Journal of Biomedical Sciences, 2014 Chronic hepatitis B virus (HBV) infection can cause hepatocellular carcinoma (HCC). Several hypotheses have been proposed to explain the mechanisms of HBV tumorigenesis, including inflammation and liver regeneration associated with cytotoxic immune ...
I. Su +6 more
semanticscholar +1 more source
Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]
, 2020 To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju +13 more
core
Mutant p53 as a Regulator and Target of Autophagy
Frontiers in Oncology, 2021 One of the most notoriously altered genes in human cancer is the tumor-suppressor TP53, which is mutated with high frequency in more cancers than any other tumor suppressor gene.
Yong Shi +2 more
doaj +1 more source
Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]
, 2004 Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core +1 more source
Deciphering the significance of p53 mutant proteins.
Trends in Cell BiologyMutations in the p53 gene compromise its role as guardian of genomic integrity, yielding predominantly missense p53 mutant proteins. The gain-of-function hypothesis has long suggested that these mutant proteins acquire new oncogenic properties; however ...
Alessio Butera, I. Amelio
semanticscholar +1 more source