Results 71 to 80 of about 6,880,999 (291)

Modeling ATM mutant proteins from missense changes confirms retained kinase activity

Human Mutation, 2009
Ataxia‐telangiectasia mutated (ATM) is the gene mutated in the cancer‐predisposing disorder ataxia‐telangiectasia (A‐T). We modeled ATM sequence variants identified in UK A‐T patients to determine the stability and kinase activity of the resulting ...
G. Barone, A. Groom, A. Reiman, V. Srinivasan, P. Byrd, A. Taylor   +5 more
semanticscholar   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

In Silico Modeling of a Mutant Cas9 Protein for High-Fidelity Genome Editing [PDF]

مجله انفورماتیک سلامت و زیست پزشکی
Introduction: CRISPR/Cas system is a bacterial-acquired immune system against viruses. spCas9 protein-derived from Streptococcus pyogenes is the most common Cas protein used in genome editing. The Cas9 proteins suffer from some problems like unwanted off-
Mahsa Ghasemi, Javad Zamani, Zarrin Minuchehr, Mehdi Shamsara   +3 more
doaj  

Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase

PLoS ONE, 2009
Background The circadian clock of the cyanobacterium Synechococcus elongatus can be reconstituted in vitro by three proteins, KaiA, KaiB and KaiC. Homo-hexameric KaiC displays kinase, phosphatase and ATPase activities; KaiA enhances KaiC phosphorylation ...
R. Pattanayek, Tetsuya Mori, Yao Xu, Sabuj Pattanayek, C. Johnson, M. Egli   +5 more
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Mutant p53: multiple mechanisms define biologic activity in cancer

Frontiers in Oncology, 2015
The functional importance of p53 as a tumor suppressor gene is evident through its pervasiveness in cancer biology. The p53 gene is the most commonly altered gene in human cancer; however, not all genetic alterations are biologically equivalent.
Michael Paul Kim, Michael Paul Kim, Yun eZhang, Guillermina eLozano   +3 more
doaj   +1 more source

Selective processing and metabolism of disease-causing mutant prion proteins. [PDF]

PLoS Pathogens, 2009
Prion diseases are fatal neurodegenerative disorders caused by aberrant metabolism of the cellular prion protein (PrP(C)). In genetic forms of these diseases, mutations in the globular C-terminal domain are hypothesized to favor the spontaneous ...
Aarthi Ashok, Ramanujan S Hegde
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord

Frontiers in Cellular Neuroscience, 2018
The molecular mechanisms leading to motor neuron death in amyotrophic lateral sclerosis (ALS) are unknown; however, several studies have provided evidence of a central role for intrinsic apoptosis.
Nathan Duval, Whitney A. Sumner, Anna G. Andrianakos, Josie J. Gray, Ron J. Bouchard, Heather M. Wilkins, Daniel A. Linseman   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source