Results 181 to 190 of about 1,981,585 (256)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A Migraine-Associated Na/K-ATPase Mutation Disrupts Hepatic Glucose Uptake and Peripheral Metabolism in Mice. [PDF]

Acta Physiol (Oxf)
Pessoa MT, Sidarala V, Pierre SV.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Does disease ontogeny matter more than JAK2 mutation status in acute myeloid leukemia? [PDF]

Cancer
Babu NS, Sangeetha KSS.
europepmc   +1 more source

Allele frequencies at recessive disease genes are mainly determined by pleiotropic effects in heterozygotes. [PDF]

Genetics
Judd J, Spence JP, Milind N, Kachuri L, Witte JS, Pritchard JK.   +5 more
europepmc   +1 more source

Integrating Molecular Classification Based on FGFR3, KRAS, HRAS, and TP53 Mutation With TNM Staging Modestly Improves Prediction of Prognosis of Upper Tract Urothelial Carcinoma After Surgery. [PDF]

Int J Urol
Yanagida K, Takada I, Ishida T, Takei K, Kishitani K, Minagawa H, Kawai T, Kaneko T, Sasajima Y, Nakagawa T.   +9 more
europepmc   +1 more source

Driver mutation impact in Chinese hepatocellular carcinoma. [PDF]

PLoS One
Wu R, Xing H, Townsend JP.
europepmc   +1 more source

Selective context, rather than persister cycling alone, drives resistance fixation in Escherichia coli. [PDF]

NPJ Antimicrob Resist
Park G, Kim H, Song S.
europepmc   +1 more source

Mutation accumulation in a hybrid parthenogenetic vertebrate. [PDF]

Mol Biol Evol
Müller ZL, Rivera JO, Currie K, Rios Carlos HI, Rovito SM, Roelke C, Fujita M.   +6 more
europepmc   +1 more source

Determinants of mutation susceptibility along the genome are largely invariant across human tissues. [PDF]

Genome Biol
Schmalohr CL, Paul Y, Bundschuh N, Beyer A.   +3 more
europepmc   +1 more source