Results 211 to 220 of about 4,183,748 (324)

Mutation in Certain Phytopathogenic Bacteria Induced by Acenaphthene [PDF]

, 1946
P. A. Ark
openalex   +1 more source

Correction of a pathogenic gene mutation in human embryos

Nature, 2017
Hong Ma, N. Marti-Gutierrez, Park Sw, Jun Wu, Young Hee Lee, Keiichiro Suzuki, A. Koski, Dongmei Ji, T. Hayama, Riffat Ahmed, H. Darby, C. Vandyken, Yongmin Li, Eunju Kang, Park Ar, Daesik Kim, Sang-Tae Kim, Jianhui Gong, Ying Gu, D. Battaglia, Sacha A. Krieg, David M. Lee, D. Wu, D. Wolf, S. Heitner, Belmonte Jci, P. Amato, Jin-Soo Kim, S. Kaul, S. Mitalipov   +29 more
semanticscholar   +1 more source

Short Tandem Repeat (STR) Somatic Mutation in Non-Melanoma Skin Cancer (NMSC): Association with Transcriptomic Profile and Potential Implications for Therapy. [PDF]

Cancers (Basel)
Kibriya MG, Almazan A, Argos M, Islam T, Shea CR, Ahsan H, Jasmine F.   +6 more
europepmc   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Significance of Mutation Spots and Concurrent Gene Mutations on Prognosis and Clinical Outcomes in Myelodysplastic Syndromes With SF3B1 Mutation. [PDF]

Cancer Med
Liu Q, Xu F, Guo J, Xu F, Huang X, Chen J, Jin J, Zhou L, He Q, Wu D, Song L, Zhang Z, Guo C, Su J, Zhang Y, Yan M, Chang C, Li X, Wu L.   +18 more
europepmc   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Mutations and Evolution

, 1921

openalex   +1 more source

Clinical Outcome and Molecular Profile in Patients with <i>DDX41</i> Mutation Hot-Spots. [PDF]

Hematol Rep
Toumeh N, Jabban Y, Nanaa A, He R, Viswanatha D, Jevremovic D, Foran JM, Arana Yi CY, Saliba AN, Hefazi Torghabeh M, Hogan WJ, Shah MV, Mangaonkar AA, Patnaik MM, Alkhateeb HB, Al-Kali A.   +15 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source