Results 221 to 230 of about 1,763,257 (296)

Characterization of the heterogeneity in SARS-CoV-2 fitness dynamics via graph representation learning. [PDF]

PLoS Comput Biol
Wang Z, Zhou Z, Wang J, Yang L, Zhang Z, Xu W, Liu Z, Ge Y, Yang L, Wang X, Yang P, Wang Q, Cao Y, Guo Y, Tian H.   +14 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A novel gain-of-function mutation <i>SCN5A</i>-N470K associated with African American familial atrial fibrillation. [PDF]

Am J Cardiovasc Dis
Cao X, Darbar FA, Wu X, Zhang L, Darbar D, Hong L.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Characterization of Korean Colorectal Cancer Reveals Novel Driver Gene and Clinically Relevant Mutations. [PDF]

MedComm (2020)
Kang J, Lim DM, Kim YJ, Shim H, Kim TY, Park KJ, Kang SB, Yu CS, Lee JL, Yu Y, Lee H, Kwon EJ, Kim HM, Mun S, Kwak D, Lee HS, Heo HJ, Kim EK, Baek SE, Park JW, Bae SU, Kwon TK, Lee D, Kim K, Oh CK, Ko DS, Cho S, Park HR, Kim S, Kim YH.   +29 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The value of DNA repair gene and TP53 co-mutation in predicting the response of non-small cell lung cancer to immunotherapy. [PDF]

Discov Oncol
Ye B, Wu C, Quan X, Jia X, Yao L, Lei L, Chen X.   +6 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Integrating whole-exome sequencing and scRNA-seq reveal the characteristic in one clear cell renal cell carcinoma sample arising in the setting of VHL disease. [PDF]

Sci Rep
Lu W, Jin T, Yu X, Liu Y, Lu Z, Huang S, Wen Z, Yan H, Su C, Ye Y, Huang Z, Mo Z, Yu Z.   +12 more
europepmc   +1 more source