Results 241 to 250 of about 1,763,257 (296)

Peripheral and autonomic nervous system involvement in spinocerebellar ataxia type 3: unveiling an invisible burden. [PDF]

J Neurol
Leeuwenberg KE, van Alfen N, van de Warrenburg BP, Maas RPPWM.   +3 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Dominant TET2 mutations predict adverse prognosis in cytogenetically normal acute myeloid leukemia patients. [PDF]

Front Oncol
Hao Z, Xia J, Bian S, Song M, Zhang M, Feng J, Li S, Wang H, Zhang Y, Yang W, Chang J, Ren F, Huang X, Chen X, Wang H.   +14 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Acute Myeloid Leukemia With a Non-Canonical <i>FLT3</i> V491L Mutation: A Case Report With <i>Ex Vivo</i> FLT3 Inhibitors Sensitivity Testing. [PDF]

J Med Cases
Pospiech M, Ngo MP, Alrawashdeh M, Qamar U, Ali A, Tam E, Yaghmour G, Alachkar H, Ladha A.   +8 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Advances and Challenges in KRAS Mutation Detection and Clinical Implications. [PDF]

Cancers (Basel)
Mirlohi MS, Yousefi T, Razaviyan J, Nomiri S, Pishbin E, Shabani-Rad MT, Ahmadian MR, Salami S.   +7 more
europepmc   +1 more source

Gain of function p53 mutant R273H confers distinct methylation profiles and consequent YAP/TAZ signaling mediated activation of partial or full EMT states to colon tumours. [PDF]

Epigenetics Chromatin
Rani H, Subhadarshini S, Jolly MK, Mahadevan V.   +3 more
europepmc   +1 more source

A rare case of dyskeratosis congenita with DKC1 mutation presenting initially as thrombocytopenia: Case report. [PDF]

Medicine (Baltimore)
Wen R, Tian J.
europepmc   +1 more source