Results 241 to 250 of about 4,355,944 (375)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Prevalence and Clinical Characteristics Associated with KRAS Gene Mutations in Colorectal Cancer in Ecuadorian Patients: A Cross-Sectional Study. [PDF]

Cancer Manag Res
Cuji-Galarza WD, Deleg-Galarza JB, Diaz-Vallejo JA, Galván-Barrios J, Mansaray FT.   +4 more
europepmc   +1 more source

Mutational retracts and extensions of mutations [PDF]

Fundamenta Mathematicae, 1974
openaire   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

ARID1A and TERT promoter mutations in dedifferentiated meningioma

, 2015
Malak Abedalthagafi, Wenya Linda Bi, Parker Merrill, William J. Gibson, Matthew F. Rose, Ziming Du, Joshua M. Francis, Rose Du, Ian F. Dunn, Azra H. Ligon, Rameen Beroukhim, Sandro Santagata   +11 more
openalex   +1 more source

A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.

New England Journal of Medicine, 2011
N. England, M. Bonnie W. Ramsey, M. Jane Davies, N. G. M. Ch.B., Elizabeth Tullis M.D., M. S. C. Bell, Pavel D ř evínek M.D., Matthias Griese M.D., Edward F. McKone M.D., M. C. E. Wainwright, Michael W. Konstan B.S., Richard Moss M.D., Felix Ratjen M.D., Ph. Isabelle Sermet-Gaudelus, Steven M. Rowe Ph.D., Qunming Dong M.S.P.H., Sally Rodriguez Ph.D., M. K. Yen, Claudia Ordoñez M.D., M. J. S. Elborn   +19 more
semanticscholar   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

The incidence rate and gene mutation characteristics of hyperphenylalaninemia in Yunnan Province, Southwest China. [PDF]

Orphanet J Rare Dis
Wang Q, Duan J, Zhao X, Qi Z.
europepmc   +1 more source

Learning, Mutation, and Long Run Equilibria in Games

, 1993
Michihiro Kandori, G. Mailath, R. Rob
semanticscholar   +1 more source