Results 21 to 30 of about 4,183,748 (324)

Effects of γ-ray irradiation and particle size on enzymatic hydrolysis and fermentation of reed straws

Fushe yanjiu yu fushe gongyi xuebao, 2023
To explore the effects of absorbed dose and particle size on enzymatic hydrolysis and fermentation of reed straws (Phragmites australias), the straws were irradiated with γ-ray irradiation at different doses (0-500 kGy) and then passed through different ...
QI Hui, CHEN Liang, WU Xiaofen, LIU An, WANG Danyang, ZHANG Yong, DENG Ming, WANG Keqin   +7 more
doaj   +1 more source

Nivolumab in previously untreated melanoma without BRAF mutation.

New England Journal of Medicine, 2015
BACKGROUND Nivolumab was associated with higher rates of objective response than chemotherapy in a phase 3 study involving patients with ipilimumab-refractory metastatic melanoma.
C. Robert, G. Long, B. Brady, C. Dutriaux, M. Maio, L. Mortier, J. Hassel, P. Rutkowski, C. McNeil, E. Kalinka‐Warzocha, K. Savage, M. Hernberg, C. Lebbé, J. Charles, C. Mihalcioiu, V. Chiarion-Sileni, C. Mauch, F. Cognetti, A. Arance, H. Schmidt, D. Schadendorf, H. Gogas, L. Lundgren-Eriksson, C. Horak, B. Sharkey, I. Waxman, V. Atkinson, P. Ascierto   +27 more
semanticscholar   +1 more source

Radiation mutagenesis of Bacillus velezensis and its antibacterial effect on Colletotrichum gloeosporioides

Fushe yanjiu yu fushe gongyi xuebao, 2023
We used 60Co-γ ray and electron beam irradiation to mutate Bacillus velezensis to breed genetically stable mutant strains. The mutant strains were screened and re-screened by plate confrontation and the four-point method to study their antibacterial ...
XIE Hui, LIU An, CHEN Liang, WU Xiaofen, QI Hui, ZHANG Qiling, WANG Zhen, DENG Ming, WANG Keqin, LIU Suchun   +9 more
doaj   +1 more source

Effects of electron beam irradiation pretreatment on the structure and enzymatic efficiency of Phragmites australis lignocelluloses with different moisture contents

Fushe yanjiu yu fushe gongyi xuebao, 2023
The study investigated the chemical composition, supramolecular structures, particle size distribution, and enzymatic efficiency of Phragmites australis lignocelluloses (PALs) with different moisture contents and treatment with 5 MeV electron beam ...
CHEN Liang, WU Xiaofen, QI Hui, ZHANG Yong, LIU An, WANG Danyang, DENG Ming, WANG Keqin   +7 more
doaj   +1 more source

VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing.

Genome Research, 2012
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and mutations across hundreds of tumors. Here we present an analysis tool, VarScan 2, for the detection of somatic mutations and
D. Koboldt, Qunyuan Zhang, D. Larson, D. Shen, M. McLellan, Ling Lin, Christopher A. Miller, E. Mardis, L. Ding, R. Wilson   +9 more
semanticscholar   +1 more source

Separation of cellulose from Triarrhena lutarioriparia by irradiation-assisted formic acid and characterization of its enzymatic hydrolysis

Fushe yanjiu yu fushe gongyi xuebao, 2022
In this study, Triarrhena lutarioriparia was irradiated by a 5 MeV electron accelerator. The effects of temperature, formic acid concentration, and absorbed dose on the separation efficiency of cellulose from Triarrhena lutarioriparia were investigated ...
WANG Danyang, WU Xiaofen, QI Hui, CHEN Liang, LIU An, DENG Ming, WANG Keqin   +6 more
doaj   +1 more source

Are Protein Shape-Encoded Lowest-Frequency Motions a Key Phenotype Selected by Evolution?

Applied Sciences, 2023
At the very deepest molecular level, the mechanisms of life depend on the operation of proteins, the so-called “workhorses” of the cell. Proteins are nanoscale machines that transform energy into useful cellular work, such as ion or nutrient transport ...
Laura Orellana
doaj   +1 more source

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Journal of Translational Medicine, 2020
Background SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts.
M. Pachetti, B. Marini, F. Benedetti, F. Giudici, E. Mauro, P. Storici, C. Masciovecchio, S. Angeletti, M. Ciccozzi, R. Gallo, D. Zella, R. Ippodrino   +11 more
semanticscholar   +1 more source

Improved survival with vemurafenib in melanoma with BRAF V600E mutation.

New England Journal of Medicine, 2011
BACKGROUND Phase 1 and 2 clinical trials of the BRAF kinase inhibitor vemurafenib (PLX4032) have shown response rates of more than 50% in patients with metastatic melanoma with the BRAF V600E mutation. METHODS We conducted a phase 3 randomized clinical
P. Chapman, A. Hauschild, C. Robert, J. Haanen, P. Ascierto, J. Larkin, R. Dummer, C. Garbe, A. Testori, M. Maio, D. Hogg, P. Lorigan, C. Lebbé, T. Jouary, D. Schadendorf, A. Ribas, S. O'Day, J. Sosman, J. Kirkwood, A. Eggermont, B. Dréno, K. Nolop, Jiang Li, B. Nelson, J. Hou, Richard J Lee, K. Flaherty, G. McArthur   +27 more
semanticscholar   +1 more source

Author Correction: ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

Nature Communications, 2018
This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee, Seon-Joo Park, Gurusamy Hariharasudhan, Min-Ji Kim, Sung Mi Jung, Seo-Yeon Jeong, In-Youb Chang, Cheolhee Kim, Eunae Kim, Jihyeon Yu, Sangsu Bae, Ho Jin You   +11 more
doaj   +1 more source