Results 21 to 30 of about 4,297,778 (372)
Are Protein Shape-Encoded Lowest-Frequency Motions a Key Phenotype Selected by Evolution?
Applied Sciences, 2023 At the very deepest molecular level, the mechanisms of life depend on the operation of proteins, the so-called “workhorses” of the cell. Proteins are nanoscale machines that transform energy into useful cellular work, such as ion or nutrient transport ...
Laura Orellana
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Colorectal cancer prognosis: is it all mutation, mutation, mutation? [PDF]
Gut, 2005 For the 500,000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts.
Hassan, AB, Paraskeva, C
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Phenotypic diversity in mutagenized population of urdbean (Vigna mungo (L.) Hepper)
Heliyon, 2021 The present study was conducted to assess the extent of induced genetic variability and to determine the inheritance pattern of various yield contributing phenotypic traits in M2 and M3 generations of urdbean following mutagenesis with single and ...
Sonu Goyal +4 more
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Generalized Hybrid Evolutionary Algorithm Framework with a Mutation Operator Requiring no Adaptation [PDF]
, 2017 This paper presents a generalized hybrid evolutionary optimization structure that not only combines both nondeterministic and deterministic algorithms on their individual merits and distinct advantages, but also offers behaviors of the three originating ...
Chan, Lipton +4 more
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Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
Journal of Translational Medicine, 2020 Background SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts.
M. Pachetti +11 more
semanticscholar +1 more source
Bulletin des Sciences Mathématiques, 2018 We study mutations of Conway-Coxeter friezes which are compatible with mutations of cluster-tilting objects in the associated cluster category of Dynkin type $A$. More precisely, we provide a formula, relying solely on the shape of the frieze, describing how each individual entry in the frieze changes under cluster mutation.
Baur, Karin +4 more
openaire +6 more sources
Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]
, 2015 Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A. +5 more
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An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci [PDF]
, 2010 A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event
A. Eyre-Walker +60 more
core +2 more sources
Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
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