Results 21 to 30 of about 4,355,944 (375)
Efficiency of carcinogenesis with and without a mutator mutation [PDF]
Proceedings of the National Academy of Sciences, 2006 Carcinogenesis involves the acquisition of multiple genetic changes altering various cellular phenotypes. These changes occur within the fixed time period of a human lifespan, and mechanisms that accelerate this process are more likely to result in clinical cancers.
Robert A, Beckman, Lawrence A, Loeb
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Are Protein Shape-Encoded Lowest-Frequency Motions a Key Phenotype Selected by Evolution?
Applied Sciences, 2023 At the very deepest molecular level, the mechanisms of life depend on the operation of proteins, the so-called “workhorses” of the cell. Proteins are nanoscale machines that transform energy into useful cellular work, such as ion or nutrient transport ...
Laura Orellana
doaj +1 more source
Phenotypic diversity in mutagenized population of urdbean (Vigna mungo (L.) Hepper)
Heliyon, 2021 The present study was conducted to assess the extent of induced genetic variability and to determine the inheritance pattern of various yield contributing phenotypic traits in M2 and M3 generations of urdbean following mutagenesis with single and ...
Sonu Goyal +4 more
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Mutational landscape of yeast mutator strains [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Deficiencies in genome maintenance genes (so-called mutator genes) result in increased mutagenesis that impacts cell evolvability. How the mutational processes drive the evolution of genome structure is not well understood. Here, we used high-throughput sequencing to characterize the mutation events (from punctual mutations to ...
Alexandre, Serero +4 more
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Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
Journal of Translational Medicine, 2020 Background SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts.
M. Pachetti +11 more
semanticscholar +1 more source
Mutation testing from probabilistic finite state machines [PDF]
, 2007 Mutation testing traditionally involves mutating a program in order to produce a set of mutants and using these mutants in order to either estimate the effectiveness of a test suite or to drive test generation.
Hierons, RM, Merayo, MG
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Mutation Spectra and the Neutrality of Mutations [PDF]
Australian Journal of Biological Sciences, 1974 The effect of amino acid replacements on enzyme function was studied in the tJ-galactosidase of Escherichia coli. Mutants possessing 50% or less of normal enzyme activity were isolated and examined. Of 733 amino acid substitutions calculated to have occurred, only 11 reduced tJ-galactosidase activity below 50 %.
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Colorectal cancer prognosis: is it all mutation, mutation, mutation? [PDF]
Gut, 2005 For the 500,000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts.
Hassan, AB, Paraskeva, C
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Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]
, 2015 Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina +12 more
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Use of the q-Gaussian mutation in evolutionary algorithms [PDF]
, 2010 Copyright @ Springer-Verlag 2010.This paper proposes the use of the q-Gaussian mutation with self-adaptation of the shape of the mutation distribution in evolutionary algorithms.
A Obuchowicz +28 more
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