Results 31 to 40 of about 1,981,585 (256)

The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

Molecular Cancer, 2022
Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development.
Claudia Buhigas, Anne Y. Warren, Wing-Kit Leung, Hayley C. Whitaker, Hayley J. Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J. Woodcock, Sue Merson, Fiona M. Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Iñigo Martincorena, G. Steven Bova, Christopher S. Foster, Peter Campbell, Norman J. Maitland, David E. Neal, Charlie E. Massie, Andy G. Lynch, Rosalind A. Eeles, Colin S. Cooper, David C. Wedge, Daniel S. Brewer   +26 more
doaj   +1 more source

Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G

Molecular Therapy: Nucleic Acids, 2023
Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure.
Krista A. Delviks-Frankenberry, Chet R. Ojha, Kip J. Hermann, Wei-Shau Hu, Bruce E. Torbett, Vinay K. Pathak   +5 more
doaj   +1 more source

Alta prevalencia de la mutación CBS p.T191M en pacientes homocistinúricos de Colombia

, 2006
8 páginasHomocystinuria is an autosomal recessive disease most commonly caused by mutationsin cystathionine ß-synthase (CBS). In this study we present the mutation analysis of 36 Colombian individuals from 10 unrelated kindred, with 11 ...
Frank, Nina, Balcells, Susana, Bernal, Jaime, Ugarte, Magdalena, Urreizti, Roser, Bermúdez, Marta, Briceño, Ignacio, Grinberg, Daniel, Merinero, Begoña, Perez Cerdá, Celia, Jan, P. Kraus   +10 more
core   +1 more source

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

Nature Communications, 2017
MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee, Seon-Joo Park, Gurusamy Hariharasudhan, Min-Ji Kim, Sung Mi Jung, Seo-Yeon Jeong, In-Youb Chang, Cheolhee Kim, Eunae Kim, Jihyeon Yu, Sangsu Bae, Ho Jin You   +11 more
doaj   +1 more source

Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell–cell interactions [PDF]

, 2014
Variation of mutation rate at a particular site in a particular genotype, in other words mutation rate plasticity (MRP), can be caused by stress or ageing. However, mutation rate control by other factors is less well characterized.
John A. D. Aston, Aston, Elizabeth, Christopher G. Knight, Roman V. Belavkin, Knight, Christopher G., Aston, JA, Aston, John A D, Rash, BM, Knight, C. G. (Christopher G.), Elizabeth Aston, Channon, A, Krašovec, Rok; id_orcid, Knight, CG, An Kadirvel, Aston, John A. D., Forbes, S, Alastair Channon, Channon, Alastair, Knight, Christopher G.; id_orcid, Aston, E, Krašovec, Rok, Belavkin, RV, Forbes, Sarah, Aston, John A.D., Sarah Forbes, Kadirvel, Manikandan, Belavkin, Roman V., Bharat M. Rash, Kadirvel, Manikandan; id_orcid, Rash, Bharat M., Krašovec, R, Kadirvel, M, Channon, A., Belavkin, R., Krašovec, R., Aston, E., Forbes, S., Kadirvel, M., Rash, B., Knight, C., Aston, J.   +40 more
core   +1 more source

A practical guide for mutational signature analysis in hematological malignancies

Nature Communications, 2019
Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S. Puente, Herve Avet-Loiseau, Peter J. Campbell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli   +14 more
doaj   +1 more source

Use of the q-Gaussian mutation in evolutionary algorithms [PDF]

, 2010
Copyright @ Springer-Verlag 2010.This paper proposes the use of the q-Gaussian mutation with self-adaptation of the shape of the mutation distribution in evolutionary algorithms.
Yang, S, YANG, Shengxiang, Shengxiang Yang, TINOS, Renato, Renato Tinós, Tinós, R   +5 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Mutation induced by ethyl methanesulphonate and hydrazine hydrate on growth, bio-physiological, and yield attributing traits of Ajwain (Trachyspermum ammi L.)

Discover Plants
Herbal spices and human health are inextricably intertwined, and they can be utilized as medicines around the world. Global demand for ajwain production increased tremendously due to its diverse utility; it can improve the flavour and promote human ...
Saima Malik, Mohd Anas, Roshan Jahan, Gazi Abdullah, Samiullah Khan   +4 more
doaj   +1 more source

Synthesis and properties of a glyphosate isopropylamine salt slow-release agent via γ-ray irradiation

Fushe yanjiu yu fushe gongyi xuebao
To improve the rate of pesticide utilization, reduce pesticide usage, and effectively eliminate the adverse effects of pesticides on the environment, a carrier material was prepared by modifying starch using a one-step irradiation treatment. This carrier
LIU Lu, ZHANG Leping, XIE Hongke, WU Jing, WU Xiaofen, GUO Feng, ZHAO Caifeng, SHAO Sai   +7 more
doaj   +1 more source