Results 31 to 40 of about 1,415,453 (269)
Mutational landscape of yeast mutator strains [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Deficiencies in genome maintenance genes (so-called mutator genes) result in increased mutagenesis that impacts cell evolvability. How the mutational processes drive the evolution of genome structure is not well understood.
Alexandre, Serero +4 more
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Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
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Colorectal cancer prognosis: is it all mutation, mutation, mutation? [PDF]
Gut, 2005 For the 500 000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts.
Hassan, AB, Paraskeva, C
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Molecular Cancer, 2022 Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development.
Claudia Buhigas +26 more
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Molecular Therapy: Nucleic Acids, 2023 Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure.
Krista A. Delviks-Frankenberry +5 more
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ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
Nature Communications, 2017 MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee +11 more
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A practical guide for mutational signature analysis in hematological malignancies
Nature Communications, 2019 Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation
Francesco Maura +14 more
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Discover PlantsHerbal spices and human health are inextricably intertwined, and they can be utilized as medicines around the world. Global demand for ajwain production increased tremendously due to its diverse utility; it can improve the flavour and promote human ...
Saima Malik +4 more
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Fushe yanjiu yu fushe gongyi xuebaoTo improve the rate of pesticide utilization, reduce pesticide usage, and effectively eliminate the adverse effects of pesticides on the environment, a carrier material was prepared by modifying starch using a one-step irradiation treatment. This carrier
LIU Lu +7 more
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