Results 31 to 40 of about 2,716,384 (302)

Author Correction: ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

open access: yesNature Communications, 2018
This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee   +11 more
doaj   +1 more source

The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

open access: yesMolecular Cancer, 2022
Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development.
Claudia Buhigas   +26 more
doaj   +1 more source

Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay [PDF]

open access: yes, 2017
Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 mutation, while it is estimated to equal the population risk for relatives without the familial mutation (non-carriers).
Baert, Annelot   +10 more
core   +1 more source

Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G

open access: yesMolecular Therapy: Nucleic Acids, 2023
Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure.
Krista A. Delviks-Frankenberry   +5 more
doaj   +1 more source

Silting mutation in triangulated categories

open access: yes, 2011
In representation theory of algebras the notion of `mutation' often plays important roles, and two cases are well known, i.e. `cluster tilting mutation' and `exceptional mutation'.
Aihara, Takuma, Iyama, Osamu
core   +1 more source

Nonlinear Dynamics of the Rock-Paper-Scissors Game with Mutations

open access: yes, 2015
We analyze the replicator-mutator equations for the Rock-Paper-Scissors game. Various graph-theoretic patterns of mutation are considered, ranging from a single unidirectional mutation pathway between two of the species, to global bidirectional mutation ...
Strogatz, Steven H.   +1 more
core   +1 more source

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

open access: yesNature Communications, 2017
MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee   +11 more
doaj   +1 more source

Mutations and amplification of oncogenes in endometrial cancer [PDF]

open access: yes, 1999
Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
An, Han-Xiang   +5 more
core   +1 more source

Synthesis and properties of a glyphosate isopropylamine salt slow-release agent via γ-ray irradiation

open access: yesFushe yanjiu yu fushe gongyi xuebao
To improve the rate of pesticide utilization, reduce pesticide usage, and effectively eliminate the adverse effects of pesticides on the environment, a carrier material was prepared by modifying starch using a one-step irradiation treatment. This carrier
LIU Lu   +7 more
doaj   +1 more source

A practical guide for mutational signature analysis in hematological malignancies

open access: yesNature Communications, 2019
Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation
Francesco Maura   +14 more
doaj   +1 more source

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