Results 301 to 310 of about 3,006,553 (325)
Some of the next articles are maybe not open access.
Microsatellite instability: The mutator that mutates the other mutator
Nature Medicine, 1996Microsatellite mutations are useful markers of both tumor clonality and genomic instability but the origin of the mutator mutations responsible is still not well understood (pages 676–681).
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Mutation Detection and Mutation Databases
cclm, 1998AbstractDetection of mutations in genes is vital throughout biology, however, this activity is time-consuming, expensive and requires a high degree of skill. This is unsatisfactory in a field which is increasing importance. Around 10–12 methods are commonly used with some predominating.
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2021
Myeloproliferative neoplasms (MPN) patients share driver mutations in JAK2, MPL or CALR genes leading to the activation of the thrombopoietin receptor (TPOR) and downstream signaling pathways. JAK2 mutation drives all the three major entities of MPN (Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis) through the constitutive ...
Guglielmelli, Paola, Calabresi, Laura
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Myeloproliferative neoplasms (MPN) patients share driver mutations in JAK2, MPL or CALR genes leading to the activation of the thrombopoietin receptor (TPOR) and downstream signaling pathways. JAK2 mutation drives all the three major entities of MPN (Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis) through the constitutive ...
Guglielmelli, Paola, Calabresi, Laura
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Journal of Thrombosis and Haemostasis, 2011
See also Zucker M, Rosenberg N, Peretz H, Green D, Bauduer F, Zivelin A, Seligsohn U. Point mutations regarded as missense mutations cause splicing defects in the factor XI gene. This issue, pp 1977–84.
S. Duga, R. Asselta
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See also Zucker M, Rosenberg N, Peretz H, Green D, Bauduer F, Zivelin A, Seligsohn U. Point mutations regarded as missense mutations cause splicing defects in the factor XI gene. This issue, pp 1977–84.
S. Duga, R. Asselta
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1978
With the exception of repair mutagenesis, which was reviewed two years ago (RHEASE, 3), the investigations of the basic molecular mechanisms of mutation induction by chemical substances seem to have reached a certain saturation level. The different types of mutations like transitions, transversions, deletions, frameshift mutations, backbone breakage ...
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With the exception of repair mutagenesis, which was reviewed two years ago (RHEASE, 3), the investigations of the basic molecular mechanisms of mutation induction by chemical substances seem to have reached a certain saturation level. The different types of mutations like transitions, transversions, deletions, frameshift mutations, backbone breakage ...
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Nature, 1996 Directional mutation pressure, mutator mutations, and dynamics of molecular evolution
Journal of Molecular Evolution, 1993Using a general form of the directional mutation theory, this paper analyzes the effect of mutations in mutator genes on the G+C content of DNA, the frequency of substitution mutations, and evolutionary changes (cumulative mutations) under various degrees of selective constraints.
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Characterization of the mutator mutation mut5-1
Molecular and General Genetics MGG, 1979The mutator mutation mut5-1 has been characterized with respect to a range of parameters which have been used to describe DNA repair mutants of yeast. No marked effect of the mutation on UV-mutability at lower doses was apparent. Diploids homozygous for the mutation are deficient in UV-induced recombination between the alleles his1-1 and hist1-315 ...
P. J. Hastings, D. P. Morrison
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2017
Chapter 2 portrays Active – Back Sooner as ‘it’ starts to disintegrate. It shows how upon arrival in one of the municipal units charged with the implementation of the trial, the original project design is undermined and recreated by the multiple local concerns to which it must adapt or defer.
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Chapter 2 portrays Active – Back Sooner as ‘it’ starts to disintegrate. It shows how upon arrival in one of the municipal units charged with the implementation of the trial, the original project design is undermined and recreated by the multiple local concerns to which it must adapt or defer.
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