Results 61 to 70 of about 87,531 (297)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Characterization of wheat oligo‐tiller mutant ot2 and fine mapping of the mutant gene Taot2

The Plant Genome
Tiller number is a crucial determinant of grain yield in wheat (Triticum aestivum L.), and identifying functional alleles can enhance our understanding of wheat tiller development. Here, we describe the ot2 wheat mutant, which exhibits a 91% reduction in
Chenxi Wang, Jiaxing Bai, Hongchun Xiong, Yongdun Xie, Jiayu Gu, Linshu Zhao, Huiyuan Li, Yuping Ding, Xinmei Guo, Huijun Guo, Luxiang Liu   +10 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Sensitivity of methods for estimating breeding values using genetic markers to the number of QTL and distribution of QTL variance

, 2010
The objective of this simulation study was to compare the effect of the number of QTL and distribution of QTL variance on the accuracy of breeding values estimated with genomewide markers (MEBV).
Bovenhuis, H., Bastiaansen John WM, Bovenhuis Henk, van Arendonk Johan AM, Calus Mario PL, John W. M. Bastiaansen, Mario P. L. Calus, Coster, A., Albart Coster, Henk Bovenhuis, Bastiaansen, J.W.M., Calus, M.P.L., Johan A. M. van Arendonk, Arendonk, J.A.M., van, van Arendonk, J.A.M., Coster Albart   +15 more
core   +1 more source

Genetic Analysis and Fine Mapping of QTL for the Erect Leaf in Mutant mths29 Induced through Fast Neutron in Wheat

Biology
The erect leaf plays a crucial role in determining plant architecture, with its growth and development regulated by genetic factors. However, there has been a lack of comprehensive studies on the regulatory mechanisms governing wheat lamina joint ...
Zhixin Yang, Jiayu Gu, Minghui Zhao, Xiaofeng Fan, Huijun Guo, Yongdun Xie, Jinfeng Zhang, Hongchun Xiong, Linshu Zhao, Shirong Zhao, Yuping Ding, Fuquan Kong, Li Sui, Le Xu, Luxiang Liu   +14 more
doaj   +1 more source

Assessment of mutagenic sensitivity in jasmine (Jasminum spp.) to chemical mutagen

Electronic Journal of Plant Breeding, 2018
The present experiment was carried out to determine mutagenic sensitivity on Jasmine (Jasminum spp.). In this experiment, terminal cuttings of Jasminum grandiflorum cv. White Pitchi and semi hardwood cuttings of J.
Sanchita Ghosh, M. Ganga and, A. John Joel   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Genetic analysis of environmental variation [PDF]

, 2010
Environmental variation (V-E) in a quantitative trait - variation in phenotype that cannot be explained by genetic variation or identifiable genetic differences - can be regarded as being under some degree of genetic control. Such variation may be either
HAN A. MULDER, Hill, William G., WILLIAM G. HILL, Mulder, H.A., Mulder, Han A., Hill, W.G.   +5 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source