Results 151 to 160 of about 846,289 (308)
Mutation rate and survival with ICR-170
, 1969 Mutation rate and survival with ICR ...
A. Radford, Radford, A.
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
First estimation of the spontaneous mutation rate in Diatoms
, 2019 International audienceMutations are the origin of genetic diversity, and the mutation rate is a fundamental parameter to understand all aspects of molecular evolution.
Piganeau, Gwenael +2 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Mutation rate that mazimizes evolvability
, 2004 In this study, we calculated optimum mutation rate that maximizes the transition rate of the quasispeceis from one fitness peak to the next. We consider that quasispecies is localized at a fitness peak, and each of quasispecies is defined by binary ...
川口 勇生 +3 more
core
Causes and Consequences of the Evolution of Mutation Rate [PDF]
, 2019 As the ultimate source of all genetic variation, mutation is required for evolution. The mutation rate measures the rate at which mutations occur over time.
Zhang, Bingjun 1984-
core
Probabilities of resistance depending on mutation rate.
, 2019 Probabilities of resistance depending on mutation rate.
Masayuki Maeda (2424859) +1 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Bayesian posterior estimates for mutation rate.
, 2012 Bayesian posterior estimates for mutation rate.
R. Zachariah Aandahl (155002) +3 more
core +1 more source