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Estimation of Spontaneous Mutation Rates
Biometrics, 2003Summary. Spontaneous or randomly occurring mutations play a key role in cancer progression. Estimation of the mutation rate of cancer cells can provide useful information about the disease. To ascertain these mutation rates, we need mathematical models that describe the distribution of mutant cells.
Natarajan, Loki +2 more
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On the mutation rate of neurofibromatosis
Human Genetics, 1975A genetic study of 124 cases of neurofibromatosis was performed. The contingent of probands was mainly represented by a Russian population, most of the individuals being born in the European part of the RSFSR. Both parents of the probands were examined in only 58 cases, the proportion of sporadic cases in this group being 0.79, as compared to 0.77 for ...
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The coevolution of mutation rates
1995In order to better understand life, it is helpful to look beyond the envelop of life as we know it. A simple model of coevolution was implemented with the addition of genes for longevity and mutation rate in the individuals. This made it possible for a lineage to evolve to be immortal.
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Sex biases in the mutation rate
Trends in Genetics, 1998Men have more germ-line cell divisions than women. Does this lead to a higher mutation rate in males? Most estimates of the proportion of mutations originating in men come either from direct observation of disease-inducing mutations or from analysis of the relative rate of evolution of sex-linked and autosomal genes in primates.
L D, Hurst, H, Ellegren
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A robust estimator of mutation rates
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2009Fluctuation analysis is an established and widely used technique of estimating mutation rates in cultured cells. This paper presents a modified median estimator of mutation rates, which is novel because it allows for unequal population sizes N(t) of the parallel cultures, and helps to detect and reduce the estimation variability.
Xiaowei, Wu +5 more
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Evolution with Changing Mutation Rates
Journal of Economic Theory, 1998zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Clone selection and the mutation rate
Theoretical Population Biology, 1975Abstract A statistical model for mutation and selection is formulated for organisms that reproduce by division. The mutation rate that optimizes the probability of clone survival is approximated using the theory of branching processes. However, it is shown by example that this optimizing mutation rate need not be the most advantageous mutation rate ...
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Spontaneous Mutation Rate in Drosophila
The American Naturalist, 1947The frequency of spontaneously occurring lethal mutations in the X-chromosome of the Sw-b stock of D. melanogaster was found to be higher among spermatozoa of previously unmated males 16 to 17 days, and 32 to 33 days after emergence than among 1- to 2-day old males (Table 1).
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Mutation Rate of the F Episome
Science, 1995F, Taddei, M, Radman, J A, Halliday
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