Results 91 to 100 of about 18,512,812 (309)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas. [PDF]

PLoS ONE, 2016
Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas) that inordinately and rapidly develop into colon cancer remain poorly ...
Jian Chen, Gottumukkala S Raju, Wilma Jogunoori, Vipin Menon, Avijit Majumdar, Jiun-Sheng Chen, Young Jin Gi, Yun Seong Jeong, Liem Phan, Mitchell Belkin, Shoujun Gu, Suchin Kundra, Nipun A Mistry, Jianping Zhang, Xiaoping Su, Shulin Li, Sue-Hwa Lin, Milind Javle, John S McMurray, Thomas F Rahlfs, Bibhuti Mishra, Jon White, Asif Rashid, Nicole Beauchemin, Brian R Weston, Mehnaz A Shafi, John R Stroehlein, Marta Davila, Rehan Akbani, John N Weinstein, Xifeng Wu, Lopa Mishra   +31 more
doaj   +1 more source

Exploring background mutational processes to decipher cancer genetic heterogeneity. [PDF]

Nucleic Acids Res, 2017
Much remains unknown about the progression and heterogeneity of mutational processes in different cancers and their diagnostic and clinical potential.
Goncearenco A, Rager SL, Li M, Sang QX, Rogozin IB, Panchenko AR.   +5 more
europepmc   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Evolution: Environmental Dependence of the Mutational Process [PDF]

Current Biology, 2019
Environmental dependence of mutation in microbes is well-known, but most experiments have investigated contexts in which growth rate is greatly reduced below optimum. A new experiment shows mutational variability extends to contexts in which growth is near optimum.
openaire   +3 more sources

The age incidence of any cancer can be explained by a one-mutation model [PDF]

arXiv, 2008
We propose a one mutation model for cancer with a mutation rate that increases with time. Under rather general hypotheses the number of mutations is necessarily a (non homogeneous) Poisson process with the prescribed mutation rate. We show that the cumulative probability of cancer up to time $t$ is, up to a multiplicative constant, an antiderivative of
arxiv  

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate

Scientific Reports, 2023
Cancer somatic mutations are the product of multiple mutational and repair processes, some of which are tightly associated with DNA replication. Mutation rates (MR) are known to be higher in late replication timing (RT) regions, but different processes ...
Oriya Vardi-Yaacov, Adar Yaacov, Shai Rosenberg, Itamar Simon   +3 more
doaj   +1 more source