Results 101 to 110 of about 18,996,847 (344)
Hidden Markov models lead to higher resolution maps of mutation signature activity in cancer
Genome Medicine, 2019 Knowing the activity of the mutational processes shaping a cancer genome may provide insight into tumorigenesis and personalized therapy. It is thus important to characterize the signatures of active mutational processes in patients from their patterns ...
Damian Wojtowicz +6 more
doaj +1 more source
APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. [PDF]
, 2019 Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Boichard, Amélie +8 more
core
A tug-of-war between driver and passenger mutations in cancer and other adaptive processes [PDF]
, 2014 Cancer progression is an example of a rapid adaptive process where evolving new traits is essential for survival and requires a high mutation rate. Precancerous cells acquire a few key mutations that drive rapid population growth and carcinogenesis ...
Korolev, Kirill S. +2 more
core +2 more sources
bioRxiv, 2020 Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world. It has been reported that ∼10%-15% of individuals with colorectal cancer experience a causative mutation in the known susceptibility genes, highlighting the ...
H. Dashti +7 more
semanticscholar +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Somatic mutation processes at a human minisatellite [PDF]
Human Molecular Genetics, 1997 Germline instability at human minisatellites frequently involves complex inter-allelic transfers of repeat units usually restricted to one end of the repeat array and apparently regulated by flanking DNA. In contrast, nothing is known about the structural basis of somatic instability at minisatellites.
Jeffreys, AJ, Neumann, R
openaire +3 more sources
Chloroplast microsatellites: measures of genetic diversity and the effect of homoplasy [PDF]
, 2005 Chloroplast microsatellites have been widely used in population genetic studies of conifers in recent years. However, their haplotype configurations suggest that they could have high levels of homoplasy, thus limiting the power of these molecular markers.
Doyle JJ +15 more
core +4 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Mutated genes, pathways and processes in tumours [PDF]
EMBO reports, 2010 Integration of the many available sources of cancer gene information—such as large‐scale tumour‐resequencing studies— identifies the ‘usual suspect’ genes, mutated in many tumour types, as well as different sets of mutated genes according to the specific tumour type.
Baudot, Anaïs +2 more
openaire +2 more sources
Mutation-Selection Balance: Ancestry, Load, and Maximum Principle
, 2002 We show how concepts from statistical physics, such as order parameter, thermodynamic limit, and quantum phase transition, translate into biological concepts in mutation-selection models for sequence evolution and can be used there.
Baake +64 more
core +1 more source