Results 121 to 130 of about 18,996,847 (344)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A cytoplasmic dynein tail mutation impairs motor processivity [PDF]

Nature Cell Biology, 2010
Mutations in the tail of the cytoplasmic dynein molecule have been reported to cause neurodegenerative disease in mice. The mutant mouse strain Legs at odd angles (Loa) has impaired retrograde axonal transport, but the molecular deficiencies in the mutant dynein molecule, and how they contribute to neurodegeneration, are unknown.
Ori-McKenney, Kassandra M., Xu, Jing, Gross, Steven P., Vallee, Richard B.   +3 more
openaire   +2 more sources

Single-cell mutational burden distributions in birth-death processes.

PLoS Computational Biology
Genetic mutations are footprints of cancer evolution and reveal critical dynamic parameters of tumour growth, which otherwise are hard to measure in vivo. The mutation accumulation in tumour cell populations has been described by various statistics, such
Christo Morison, Dudley Stark, Weini Huang   +2 more
doaj   +1 more source

Interpreting the dependence of mutation rates on age and time [PDF]

, 2015
Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing
Gao, Ziyue, Przeworski, Molly, Sella, Guy, Wyman, Minyoung J.   +3 more
core   +5 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas. [PDF]

PLoS ONE, 2016
Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas) that inordinately and rapidly develop into colon cancer remain poorly ...
Jian Chen, Gottumukkala S Raju, Wilma Jogunoori, Vipin Menon, Avijit Majumdar, Jiun-Sheng Chen, Young Jin Gi, Yun Seong Jeong, Liem Phan, Mitchell Belkin, Shoujun Gu, Suchin Kundra, Nipun A Mistry, Jianping Zhang, Xiaoping Su, Shulin Li, Sue-Hwa Lin, Milind Javle, John S McMurray, Thomas F Rahlfs, Bibhuti Mishra, Jon White, Asif Rashid, Nicole Beauchemin, Brian R Weston, Mehnaz A Shafi, John R Stroehlein, Marta Davila, Rehan Akbani, John N Weinstein, Xifeng Wu, Lopa Mishra   +31 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Virus Replication as a Phenotypic Version of Polynucleotide Evolution

, 2013
In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol.
A. Eyre-Walker, A. Kowald, A. Timm, C. Escarmís, C. J. Thompson, C. Meyer, C. O. Wilke, C. O. Wilke, D. A. Steinhauer, D. R. Rokyta, Diogo Castro, E. Domingo, E. Domingo, E. Lázaro, F. Antoneli, F. Antoneli, F. Gantmacher, Fernando Antoneli, Francisco Bosco, H. A. Orr, H. W. Watson, I. Leuthäusser, J. A. Capitán, J. A. Cuesta, J. A. Cuesta, J. Aguirre, J. Aguirre, J. H. Wilkinson, J. Hermisson, J. J. Bull, J. J. Bull, J. J. Bull, J. Swetina, K. B. Athreya, K. Dietz, L. Demetrius, L. Demetrius, Luiz Mario Janini, M. Delbrück, M. Eigen, M. Eigen, M. Imhof, M. Jiřina, M. Kimmel, M. Parera, M. Ziehe, P. Carrasco, P. D. Keightley, P. Domingo-Calap, P. Jagers, R. Forster, R. M. Gray, R. Miralles, R. Sanjuán, S. C. Manrubia, S. Crotty, S. F. Elena, S. F. Elena, S. Ojosnegros, S. Ojosnegros, T. G. Kurtz, T. Harris, U. Grenander, W. Feller, Y. Zhu   +64 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source