Results 191 to 200 of about 18,512,812 (309)

Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. [PDF]

, 1997
Gang Yan, Yang Fu, Denise L. Faustman
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Mutational Analysis of Plasmid R64 Thin Pilus Prepilin: the Entire Prepilin Sequence Is Required for Processing by Type IV Prepilin Peptidase [PDF]

, 1998
Takayuki Horiuchi, Teruya Komano
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Control of carbohydrate processing: the lec1A CHO mutation results in partial loss of N-acetylglucosaminyltransferase I activity.

, 1985
Pamela Stanley, William G. Chaney
openalex   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Chemical analysis and mutational assay of distilled oils from the H-coal direct liquefaction process: a status report

, 1985
Bary W. Wilson, Douglas W. Later, Cherylyn W. Wright, D.L. Stewart   +3 more
openalex   +2 more sources

Mutation of Arg273 to Leu Alters the Specificity of the Yeast N-Glycan Processing Class I α1,2-Mannosidase [PDF]

, 2000
Pedro Romero, François Vallée, P. Lynne Howell, Annetté Herscovics   +3 more
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The landscape of cancer genes and mutational processes in breast cancer

Nature, 2012
P. Stephens, P. Tarpey, H. Davies, P. Van Loo, C. Greenman, D. Wedge, S. Nik-Zainal, Sancha Martin, I. Varela, G. Bignell, L. Yates, E. Papaemmanuil, D. Beare, A. Butler, Angela M. Cheverton, John Gamble, Jonathan Hinton, Mingming Jia, Alagurevathi Jayakumar, David Jones, Calli Latimer, K. Lau, Stuart Mclaren, D. Mcbride, A. Menzies, L. Mudie, K. Raine, R. Rad, M. Spencer Chapman, J. Teague, D. Easton, A. Langerød, Rolf Ellen Bjorn Torill Lars Karesen Schlichting Naume Sauer Ottestad, R. Kåresen, E. Schlichting, B. Naume, Torill Sauer, L. Ottestad, M. Lee, Chen-Yang Shen, Benita Tan Kiat Tee, Bernice Wong Huimin, A. Broeks, A. Vargas, G. Turashvili, J. Martens, Aquila Fatima, P. Miron, S. Chin, G. Thomas, S. Boyault, O. Mariani, S. Lakhani, M. J. van de Vijver, Laura van ’t Veer, J. Foekens, C. Desmedt, C. Sotiriou, A. Tutt, C. Caldas, J. Reis-Filho, S. Aparicio, A. Salomon, A. Børresen-Dale, A. Richardson, P. Campbell, P. Futreal, M. Stratton   +67 more
semanticscholar   +1 more source