Results 271 to 280 of about 18,699,776 (340)

Population extinction by mutational load and demographic stochasticity [PDF]

, 1990
Bürger, Reinhard, Gabriel, Wilfried, Loeschcke, V., Lynch, Michael, Seitz, Alfred   +4 more
core  

Hepatitis C virus mutation affects proteasomal epitope processing [PDF]

, 2004
Ulrike Seifert, H. Liermann, Vito Racanelli, Anne Halenius, Manfred Wiese, Heiner Wedemeyer, Thomas Ruppert, Kay Rispeter, Peter Henklein, Alice J.A.M. Sijts, Hartmut Hengel, Peter‐M. Kloetzel, Barbara Rehermann   +12 more
openalex   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Codon usage between genomes is constrained by genome-wide mutational processes [PDF]

, 2004
Swaine L. Chen, William Lee, Alison K. Hottes, Lucy Shapiro, Harley H. McAdams   +4 more
openalex   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Mutation of the Zinc-Binding Metalloprotease Motif AffectsBacteroides fragilisToxin Activity but Does Not Affect Propeptide Processing [PDF]

, 2005
Augusto A. Franco, Simy L. Buckwold, Jai W. Shin, Miguel Ascon, Cynthia L. Sears   +4 more
openalex   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

Science Translational Medicine, 2015
N. Mcgranahan, F. Favero, E. D. de Bruin, Nicolai J. Birkbak, Z. Szallasi, C. Swanton   +5 more
semanticscholar   +1 more source

Chromosomal phylogeny of Robertsonian races of the house mouse on the island of Madeira: testing between alternative mutational processes [PDF]

, 2005
Janice Britton‐Davidian, Josette Catalan, Maria da Graça Ramalhinho, Jean‐Christophe Auffray, Ana Cláudia Nunes, Élodie Gazave, Jeremy B. Searle, María da Luz Mathias   +7 more
openalex   +1 more source