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Estimating the mutation risks conferred by mutational processes
2023DNA mutations can disrupt vital cellular functions leading to disase. One of the most striking examples is cancer, which requires mutations disturbing the activity of cancer driver genes. The risk at which these genes are mutated is not equal across mutational processes, as certain positions in the genome have been shown to exhibit considerable ...
Rosendahl Huber, A. K. M. +3 more
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Yeast suppressor mutations and transfer RNA processing
1990Publisher Summary Transfer RNA molecules are essential for protein synthesis in all organisms. Once mature-sized tRNAs are produced, further interactions with enzymes or structural proteins are necessary for their use in protein biosynthesis: transport from the nucleus to the cytoplasm, aminoacylation by the cognate aminoacyl-tRNA synthetase, binding
M, Nichols, I, Willis, D, Söll
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Microsatellites: evolution and mutational processes.
Ciba Foundation symposium, 1996Microsatellites (simple sequence repeats) are ubiquitous in eukaryotic genomes, and they are highly polymorphic. They are currently the primary tools for most genetic mapping and for studies comparing the differentiation of human and other mammalian populations.
N B, Freimer, M, Slatkin
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Cytokine Sensitivity and N‐Glycan Processing Mutations
2006The EGF and TGF-beta families of cytokines are critical regulators of cell proliferation, morphogenesis, and tissue repair. The signaling pathways downstream of EGF and TGF-beta receptors also contribute to cancer growth and metastasis. Cytokine receptors are glycoproteins, and we have recently shown that GlcNAc-branching of N-glycans enhances their ...
Emily A, Partridge +2 more
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[Mutation process in mini-satellites].
Tsitologiia, 1998Minisatellites are tandemly repeated DNA sequences with repeat units in the range 6-100 bp. They are preferentially located in subtelomeric euchromatin of chromosomes of higher eukaryotes. Minisatellite loci frequently show variability in allele length.
B E, Marchenko, O I, Podgornaia
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Molecular imaging in oncology: Current impact and future directions
Ca-A Cancer Journal for Clinicians, 2022Steven P Rowe, Martin G Pomper
exaly