Results 321 to 330 of about 18,699,776 (340)
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Mutational signatures and processes in hepatobiliary cancers
Nature Reviews Gastroenterology & Hepatology, 2022The evolutionary history of hepatobiliary cancers is embedded in their genomes. By analysing their catalogue of somatic mutations and the DNA sequence context in which they occur, it is possible to infer the mechanisms underpinning tumorigenesis. These mutational signatures reflect the exogenous and endogenous origins of genetic damage as well as the ...
E. Zhuravleva, C. O'Rourke, J. Andersen
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Hidden role of mutations in the evolutionary process
Physical Review E, 2021Mutations not only alter allele frequencies in a genetic pool but may also determine the fate of an evolutionary process. Here we study which allele fixes in a one-step, one-way model including the wild type and two adaptive mutations. We study the effect of the four basic evolutionary mechanisms-genetic drift, natural selection, mutation, and gene ...
Alexandre de Aquino Soares +3 more
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Distinct Mutational Processes Influence Germline DNA Mutations
Cancer Discovery, 2021Abstract Nine distinct mutational processes underlie human germline mutations.
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Mutational process and microevolution
Genetica, 1980Long term observations of the gene pool of the same and geographically separated populations of Drosophila melanogaster forced us to return to the old idea of De Vries about the existence of mutation periods and fluctuations in the mutation rate with time. A 3- to 5-fold increase of the total mutation rate was estimated by the frequency of lethals, and
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Microsatellites: evolution and mutational processes.
Ciba Foundation symposium, 1996Microsatellites (simple sequence repeats) are ubiquitous in eukaryotic genomes, and they are highly polymorphic. They are currently the primary tools for most genetic mapping and for studies comparing the differentiation of human and other mammalian populations.
Montgomery Slatkin, Nelson B. Freimer
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Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid
Seminars in liver disease (Print), 2019Each hepatocellular carcinoma displays dozens of mutations in driver and passenger genes. The analysis of the types of substitutions and their trinucleotide context defines mutational signatures that recapitulate the endogenous and exogenous mutational ...
J. Nault, E. Letouzé
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A law of small numbers for a mutation process
Mathematical Biosciences, 1989A system of particles will consist of 2n particles at time n, n = 0,1,2,...; each of the particles is either blue or white. At time 0 the particle is white. In the time interval (0,1) this particle mutates to blue with probability p. At time 1 the particle splits into two particles of the same color.
Howard G. Tucker, Mark Finkelstein
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The Mutation Process in Colored Coalescent Theory
Bulletin of Mathematical Biology, 2009The mutation process is introduced into the colored coalescent theory. The mutation process can be viewed as an independent Poisson process running on the colored genealogical random tree generated by the colored coalescent process, with the edge lengths of the random tree serving as the time scale for the mutation process.
Jianjun Paul Tian, Xiao-Song Lin
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FROM THE MUTATION THEORY TO THE THEORY OF THE MUTATION PROCESS
2006The main contributions to the biology made by N.V. Timofeev-Ressovsky and his co-authors (in "three gentlemen paper", 1935) were: radiobiological approach to the mutation process, materialization of the gene as a macromolecule and foundation of molecular biology.
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Regulatory processes and the origins of spontaneous mutations
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1994A review of information currently available about the origins of spontaneous mutational events suggests that there may be a role for known cellular control mechanisms in determining the frequencies with which such events can occur. Attention is also directed to recent findings with antimutator (dnaE) mutants of Escherichia coli which indicate that the ...
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