Results 61 to 70 of about 18,996,847 (344)

Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii [PDF]

, 2014
Estimates of mutational parameters, such as the average fitness effect of a new mutation and the rate at which new genetic variation for fitness is created by mutation, are important for the understanding of many biological processes. However, the causes
Adams, Baer, Baer, Baranyi, Barrick, Bateman, Charlesworth, Charlesworth, Crutchfield, Davies, Dickinson, Drake, Fernandez, Fisher, Fry, García-Dorado, Goffeau, Goho, Gong, Haerty, Halligan, Halligan, Hartfield, Joseph, Keightley, Keightley, Keightley, Keightley, Keightley, Keightley, Kibota, Knight, Kondrashov, Koonin, Liss, Loewe, Lukjancenko, Lynch, Lynch, Lynch, Lynch, Massey, Matic, Merchant, Mukai, Mukai, Ness, Otto, R Core Team, Schaack, Schoen, Schrider, Schultz, Sharp, Shaw, Smith, Sokal, Sousa, Sundin, Sung, The Arabadopsis, The C. elegans Sequencing Consortium, Torgerson, Winzeler, Zeyl, Zuur   +65 more
core   +1 more source

Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes

bioRxiv, 2021
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability patterned by distinct mutational processes, intratumoral heterogeneity and intraperitoneal spread.
I. Vázquez-García, F. Uhlitz, Nicholas Ceglia, J. Lim, Michelle Wu, Neeman Mohibullah, A. Ruiz, K. Boehm, V. Bojilova, Christopher J. Fong, Tyler Funnell, Diljot S. Grewal, Eliyahu Havasov, Samantha Leung, Arfath Pasha, Druv M. Patel, Maryam Pourmaleki, Nicole Rusk, Hongyu Shi, R. Vanguri, Marc J. Williams, Allen W. Zhang, V. Broach, D. Chi, A. Da Cruz Paula, G. Gardner, Sarah H. Kim, M. Lennon, K. Roche, Y. Sonoda, O. Zivanovic, Ritika Kundra, A. Viale, F. Derakhshan, Luke Geneslaw, A. Maroldi, Rahelly Nunez, F. Pareja, A. Stylianou, M. Vahdatinia, Y. Bykov, R. Grisham, Ying L. Liu, Y. Lakhman, I. Nikolovski, D. Kelly, Jianjiong Gao, A. Schietinger, T. Hollmann, S. Bakhoum, R. Soslow, Lora H. Ellenson, N. Abu-Rustum, C. Aghajanian, C. Friedman, A. McPherson, B. Weigelt, D. Zamarin, Sohrab P. Shah   +58 more
semanticscholar   +1 more source

Biochemical reconstitution of heat-induced mutational processes. [PDF]

PLoS One
Non-enzymatic spontaneous deamination of 5-methylcytosine, producing thymine, is the proposed etiology of cancer mutational signature 1, which is the most predominant signature in all cancers. Here, the proposed mutational process was reconstituted using synthetic DNA and purified proteins.
Sugiyama T.
europepmc   +3 more sources

Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population

BMC Genomics, 2018
Background Esophageal squamous cell carcinomas (ESCC) is the fourth most lethal cancer in China. Previous studies reveal several highly conserved mutational processes in ESCC.
Jintao Guo, Jiankun Huang, Ying Zhou, Yulin Zhou, Liying Yu, Huili Li, Lingyun Hou, Liuwei Zhu, Dandan Ge, Yuanyuan Zeng, Bayasi Guleng, Qiyuan Li   +11 more
doaj   +1 more source

A practical framework RNMF for exploring the association between mutational signatures and genes using gene cumulative contribution abundance

Cancer Medicine, 2022
Background Mutational signatures are somatic mutation patterns enriching operational mutational processes, which can provide abundant information about the mechanism of cancer.
Zhenzhang Li, Haihua Liang, Shaoan Zhang, Wen Luo   +3 more
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target [PDF]

, 2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy.
Abate F., Agostinelli C., Amente S., Berti E., Bertolini F., Brundu F., Cerroni L., Dellino G. I., Etebari M., Facchetti F., Falini B., Fuligni F., Indio V., Laginestra M. A., Melle F., Motta G., Orecchioni S., Paulli M., Piccioni R., Pileri A., Pileri S. A., Pimpinelli N., Rabadan R., Rossi M., Sabattini E., Sapienza M. R., Tabanelli V., Talarico G., Tarantino G., Tripodo C., Truni M.   +30 more
core   +2 more sources

The impact of mutational processes on structural genomic plasticity in cancer cells

bioRxiv, 2021
Structural genome alterations are determinants of cancer ontogeny and therapeutic response. While bulk genome sequencing has enabled delineation of structural variation (SV) mutational processes which generate patterns of DNA damage, we have little ...
Tyler Funnell, C. O’Flanagan, Marc J. Williams, A. McPherson, S. McKinney, Farhia Kabeer, Hakwoo Lee, T. Masud, P. Eirew, Damian Boon Siew Yap, Allen W. Zhang, J. Lim, Beixi Wang, Jazmine Brimhall, Justina Biele, J. Ting, Y. Liu, S. Beatty, D. Lai, Jenifer Pham, Diljot S. Grewal, Douglas Abrams, Eliyahu Havasov, Samantha Leung, V. Bojilova, Richard A. Moore, Nicole Rusk, F. Uhlitz, Nicholas Ceglia, A. Weiner, J. M. Douglas, D. Zamarin, B. Weigelt, Sarah H. Kim, A. Da Cruz Paula, J. Reis-Filho, Yangguang Li, Hong Xu, Teresa Ruiz de Algara, So Ra Lee, Viviana Cerda Llanos, Sohrab P. Shah, Samuel Aparicio   +42 more
semanticscholar   +1 more source

Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia [PDF]

Molecular & Cellular Oncology, 2016
Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes-2 types of activation induced-cytidine deaminase (AID) signatures and an aging
Kasar, S., Brown, J. R.
openaire   +3 more sources

A data-driven approach for constructing mutation categories for mutational signature analysis.

PLoS Computational Biology, 2021
Mutational processes shape the genomes of cancer patients and their understanding has important applications in diagnosis and treatment. Current modeling of mutational processes by identifying their characteristic signatures views each base substitution ...
Gal Gilad, Mark D M Leiserson, Roded Sharan   +2 more
doaj   +1 more source

Functional Bias and Spatial Organization of Genes in Mutational Hot and Cold Regions in the Human Genome [PDF]

, 2004
The neutral mutation rate is known to vary widely along human chromosomes, leading to mutational hot and cold regions. We provide evidence that categories of functionally-related genes reside preferentially in mutationally hot or cold regions, the size ...
Chuang, Jeffrey H., Li, Hao
core   +5 more sources