Results 71 to 80 of about 18,996,847 (344)

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Genome Biology, 2016
Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts.
R. Rosenthal, N. Mcgranahan, Javier Herrero, B. Taylor, C. Swanton   +4 more
semanticscholar   +1 more source

Mutational spectra are associated with bacterial niche

Nature Communications, 2023
As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells.
Christopher Ruis, Aaron Weimann, Gerry Tonkin-Hill, Arun Prasad Pandurangan, Marta Matuszewska, Gemma G. R. Murray, Roger C. Lévesque, Tom L. Blundell, R. Andres Floto, Julian Parkhill   +9 more
doaj   +1 more source

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis [PDF]

, 2014
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes.
Anderson, M, Bailey, P, Barbour, A, Bruxner, T, Campbell, P, Christ, A, Fink, J, Gotley, D, Grimmond, S, Harliwong, I, Hayward, N, Holmes, O, Hussey, D, Idrisoglu, S, Kazakoff, S, Krause, L, Lampe, G, Leonard, C, Loffler, K, Lord, R, Manning, S, Miller, D, Nancarrow, D, Newell, F, Nones, K, Nourbakhsh, E, Nourse, C, Patch, A, Pearson, J, Phillips, W, Quek, K, Quinn, M, Reid, L, Simpson, P, Smithers, B, Tang, Y, Waddell, N, Waddell, N, Watson, D, Wayte, N, Whiteman, D, Wilson, P, Wood, S, Xu, Q   +43 more
core   +4 more sources

Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers [PDF]

, 2018
Throughout their lifetime, cells are subject to extrinsic and intrinsic mutational processes leaving behind characteristic signatures in the genome.
Campbell, Peter J., Gartner, Anton, Gerstung, Moritz, Hong, Ye, Meier, Bettina, Schofield, Pieta, Volkova, Nadezda V.   +6 more
core   +3 more sources

SigsPack, a package for cancer mutational signatures

BMC Bioinformatics, 2019
Background Mutational signatures are specific patterns of somatic mutations introduced into the genome by oncogenic processes. Several mutational signatures have been identified and quantified from multiple cancer studies, and some of them have been ...
Franziska Schumann, Eric Blanc, Clemens Messerschmidt, Thomas Blankenstein, Antonia Busse, Dieter Beule   +5 more
doaj   +1 more source

Influence network model uncovers relations between biological processes and mutational signatures

Genome Medicine, 2023
Background There has been a growing appreciation recently that mutagenic processes can be studied through the lenses of mutational signatures, which represent characteristic mutation patterns attributed to individual mutagens.
Bayarbaatar Amgalan, Damian Wojtowicz, Yoo-Ah Kim, Teresa M. Przytycka   +3 more
doaj   +1 more source

Pan-Cancer Analysis for Immune Cell Infiltration and Mutational Signatures Using Non-Negative Canonical Correlation Analysis

Applied Sciences, 2022
Mutational signatures indicate the mutational processes and substitution patterns in cancer cell genomes. However, the functional consequences of mutational signatures remain unclear, and there have been no comprehensive systematic studies to examine the
Je-Keun Rhee
doaj   +1 more source

Accuracy of mutational signature software on correlated signatures

Scientific Reports, 2022
Mutational signatures are characteristic patterns of mutations generated by exogenous mutagens or by endogenous mutational processes. Mutational signatures are important for research into DNA damage and repair, aging, cancer biology, genetic toxicology ...
Yang Wu, Ellora Hui Zhen Chua, Alvin Wei Tian Ng, Arnoud Boot, Steven G. Rozen   +4 more
doaj   +1 more source

Estimating translational selection in Eukaryotic Genomes [PDF]

, 2009
Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the ...
Adams, Akashi, Akashi, Akashi, Akashi, Akashi, Akashi, Bennetzen, Birdsell, Bulmer, Bulmer, Chamary, Coghlan, Comeron, Cutter, dos Reis, Duret, Eyre-Walker, Eyre-Walker, Friedman, Harpending, Hartl, Holstege, Ikemura, Ikemura, Kanaya, Koonin, L. Wernisch, Lafay, Lander, Lowe, Lynch, M. dos Reis, Maside, Percudani, Reis, Sharp, Sharp, Sharp, Sherry, The C. elegans Sequencing Consortium, Urrutia, Wang, Wright   +43 more
core   +2 more sources

The impact of rare germline variants on human somatic mutation processes

Nature Communications, 2022
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences on mutation processes are known.
Mischan Vali-Pour, Solip Park, Jose Espinosa-Carrasco, Daniel Ortiz-Martínez, Ben Lehner, Fran Supek   +5 more
doaj   +1 more source