Results 81 to 90 of about 18,996,847 (344)

Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]

, 2013
To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare.
Neher, Richard A.
core   +1 more source

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events

BMC Genomics, 2019
Background Cancer genomes are peppered with somatic mutations imprinted by different mutational processes. The mutational pattern of a cancer genome can be used to identify and understand the etiology of the underlying mutational processes. A plethora of
Erik N. Bergstrom, Mi Ni Huang, Uma Mahto, Mark Barnes, Michael R. Stratton, Steven G. Rozen, Ludmil B. Alexandrov   +6 more
doaj   +1 more source

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer. [PDF]

, 2017
Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution.
Bivona, Trever G, Cai, Mei-Chun, Chen, Hong-Zhuan, Chen, Minjiang, Fu, Yujie, Gao, Wei-Qiang, Gu, Zhenyu, Jing, Ying, Ma, Pengfei, Shen, Ying, Wang, Mengzhao, Wu, Jie, Yan, Ying, Zhang, Shengzhe, Zhao, Xiaojing, Zhu, Liang, Zhuang, Guanglei   +16 more
core   +2 more sources

Inferring active mutational processes in cancer using single cell sequencing and evolutionary constraints

bioRxiv
Ongoing mutagenesis in cancer drives genetic diversity throughout the natural history of cancers. As the activities of mutational processes are dynamic throughout evolution, distinguishing the mutational signatures of ‘active’ and ‘historical’ processes ...
Gryte Satas, Matthew A. Myers, Andrew Mcpherson, Sohrab P. Shah   +3 more
semanticscholar   +1 more source

Somatic mutations render human exome and pathogen DNA more similar

, 2019
Immunotherapy has recently shown important clinical successes in a substantial number of oncology indications. Additionally, the tumor somatic mutation load has been shown to associate with response to these therapeutic agents, and specific mutational ...
Cristescu, Razvan, Ebrahimzadeh, Ehsan, Engler, Maggie, Tchamkerten, Aslan, Tse, David   +4 more
core   +1 more source

Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness? [PDF]

, 2010
In the past few years, numerous research projects have focused on identifying and understanding scaling properties in the gene content of prokaryote genomes and the intricacy of their regulation networks.
Adami, Balleza, C. Knibbe, Cases, Cordero, D.P. Parsons, Dittrich, Drake, Drake, Elena, Foster, G. Beslon, Itzkovitz, J.-M. Peña, Janga, Knibbe, Knibbe, Knibbe, Konstantinidis, Koonin, Lenski, Luscombe, Maslov, Molina, Molina, Nehaniv, Pepper, Reymond, Sniegowski, Stover, Struhl, van Nimwegen, Viñuelas, Wagner, West, West, Wilke, Y. Sanchez-Dehesa   +37 more
core   +4 more sources

Using CRISPR to understand how cancer mutations happen

Communications Biology, 2021
Somatic mutations in cancer genomes can be caused by many different mutational processes, each of which produce distinctive patterns termed “mutational signatures”.
Eve H. Rogers
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Different evolutionary paths to complexity for small and large populations of digital organisms [PDF]

, 2016
A major aim of evolutionary biology is to explain the respective roles of adaptive versus non-adaptive changes in the evolution of complexity. While selection is certainly responsible for the spread and maintenance of complex phenotypes, this does not ...
Adami, Christoph, LaBar, Thomas
core   +5 more sources

decompTumor2Sig: identification of mutational signatures active in individual tumors

BMC Bioinformatics, 2019
Background The somatic mutations found in a tumor have in most cases been caused by multiple mutational processes such as those related to extrinsic carcinogens like cigarette smoke, and those related to intrinsic processes like age-related spontaneous ...
Sandra Krüger, Rosario M. Piro
doaj   +1 more source