Results 81 to 90 of about 18,512,812 (309)
On the Fixation Process of a Beneficial Mutation in a Variable Environment [PDF]
Genetics, 2011 Abstract A population that adapts to gradual environmental change will typically experience temporal variation in its population size and the selection pressure. On the basis of the mathematical theory of inhomogeneous branching processes, we present a framework to describe the fixation process of a single beneficial allele under these ...
Uecker, H., Hermisson, J.
openaire +5 more sources
Sequential mutations in exponentially growing populations [PDF]
arXiv, 2022 Stochastic models of sequential mutation acquisition are widely used to quantify cancer and bacterial evolution. Across manifold scenarios, recurrent research questions are: how many cells are there with $n$ alterations, and how long will it take for these cells to appear. For exponentially growing populations, these questions have been tackled only in
arxiv
Attribution of Cancer Origins to Endogenous, Exogenous, and Actionable Mutational Processes
, 2020 Mutational processes in tumors leave tell-tale genomic signatures composed of “passenger” mutations and mutations that have quantifiable effects on the proliferation and survival of cancer cell lineages.
Vincent L. Cannataro +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Mutation frequencies in a birth–death branching process [PDF]
The Annals of Applied Probability, 2018 First, we revisit the stochastic Luria-Delbr ck model: a classic two-type branching process which describes cell proliferation and mutation. We prove limit theorems and exact results for the mutation times, clone sizes, and number of mutants. Second, we extend the framework to consider mutations at multiple sites along the genome.
Cheek, David, Antal, Tibor
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Correlated Mixed Membership Modeling of Somatic Mutations [PDF]
arXiv, 2020 Recent studies of cancer somatic mutation profiles seek to identify mutations for targeted therapy in personalized medicine. Analysis of profiles, however, is not trivial, as each profile is heterogeneous and there are multiple confounding factors that influence the cause-and-effect relationships between cancer genes such as cancer (sub)type ...
arxiv
Mutation Rules and the Evolution of Sparseness and Modularity in Biological Systems [PDF]
PLoS ONE 8(8): e70444, 2013 Biological systems exhibit two structural features on many levels of organization: sparseness, in which only a small fraction of possible interactions between components actually occur; and modularity - the near decomposability of the system into modules with distinct functionality.
arxiv +1 more source
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Spreading processes with mutations over multilayer networks
Proceedings of the National Academy of Sciences, 2023 A key scientific challenge during the outbreak of novel infectious diseases is to predict how the course of the epidemic changes under countermeasures that limit interaction in the population. Most epidemiological models do not consider the role of mutations and heterogeneity in the type of contact events. However, pathogens have the capacity to mutate
Mansi Sood +6 more
openaire +3 more sources
Mutational signatures are markers of drug sensitivity of cancer cells
Nature Communications, 2022 Mutational signatures can reveal the impact of mutagenic processes in cancer, including exposure to therapy. Here, the authors develop an approach that can accurately predict drug responses in cancer using mutational signatures while simultaneously ...
Jurica Levatić +3 more
doaj +1 more source