Results 201 to 210 of about 2,222,994 (259)

Two Decades of <i>NPM1</i>-Mutated Acute Myeloid Leukemia: From Molecular Insights to Clinical Decision-Making. [PDF]

Cancers (Basel)
Cimino G, Caridi M, Celenza R, Millucci F, Crocioni M, Sciabolacci S, Cardinali V, Martelli MP.   +7 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Theoretical estimates on the expected number of mutations needed to reconstruct clonal lineage trees. [PDF]

Bioinform Adv
Bristy NA, Schwartz R.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage. [PDF]

NPJ Precis Oncol
Heinzl N, Ghezelayagh TS, Wang G, Kohrn BF, Katz R, Coombes C, Smith TH, Norgaard ZK, Lo FY, Schmidt EK, Higgins JE, Valentine CC, Filipits M, Romanens L, Labidi-Galy I, Postl M, Grimm C, Cibula D, Dostálek L, Frühauf F, Jelenek G, Plch M, Fabian P, Mustea A, Condic M, Pristauz-Telsnigg G, Tamussino K, Bouda J, Brambs CE, O'Toole S, Bischof K, Grill S, Rosenthal AN, Vanderstichele A, Oppelt P, Rinda Soong T, Norquist BM, Salk JJ, Zeillinger R, Speiser P, Risques RA.   +40 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

AML, Myelodysplasia-Related: Beyond Classification-Toward Precision Decision-Making. [PDF]

Mediterr J Hematol Infect Dis
Leone G, Testa U, Attardi E, Maria Teresa V.   +3 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source