Results 221 to 230 of about 2,222,994 (259)

Prognostic and therapeutic implications of BRCA1 and BRCA2 mutations in ovarian cancer. [PDF]

Front Oncol
Pawul W, Opoka P, Dusza A, Blajerski B, Orzelska J, Gierulska N, Kułak K, Tarkowski R.   +7 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Simulating the host niche: balancing complexity and control in the experimental evolution of antibiotic resistance and pathoadaptation. [PDF]

Microbiology (Reading)
Hernandez-Bird J, Meirelles LA.
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

In Host Mutational Adaptation of Mycobacterium Tuberculosis Complex Strains During Tuberculosis Infection. [PDF]

J Infect Dis
Zhang H, Medina-Jaudes N, Forcada-Nadal A, Harrison EM, Coll F.   +4 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

KRAS in Colorectal Cancer: Tumorigenesis, Surgical Implications and Evolving Treatment Target. [PDF]

Curr Oncol
Iftikhar S, Xiao AH, Jin Z, Aly EH.
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The Roles of Genetic and Epigenetic Abnormalities in Essential Thrombocythemia. [PDF]

Genes (Basel)
Strzała D, Homenda W, Połom A, Kellas A, Bilska S, Paszek S, Potocka-Wojtowicz N, Zawlik I.   +7 more
europepmc   +1 more source

Discordant pathology following pancreatoduodenectomy for suspected intraductal papillary mucinous neoplasm: reassessment of cyst fluid genetic analysis. [PDF]

J Surg Case Rep
Sibbersen E, Patel DJ, Cheema HA, Hruban RH, Schmidt CM.   +4 more
europepmc   +1 more source