Results 221 to 230 of about 1,908,891 (267)
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Software Testing, Verification and Reliability, 2001
AbstractApplications that utilize a broker‐based architecture are often composed of components that need to be tested individually and in combination. Furthermore, adequacy assessment of tests of components is useful in that it assists testers in identifying weaknesses in the tests generated so far and in offering hints on what the new tests must be ...
Sudipto Ghosh 0001, Aditya P. Mathur
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AbstractApplications that utilize a broker‐based architecture are often composed of components that need to be tested individually and in combination. Furthermore, adequacy assessment of tests of components is useful in that it assists testers in identifying weaknesses in the tests generated so far and in offering hints on what the new tests must be ...
Sudipto Ghosh 0001, Aditya P. Mathur
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Microsatellite instability: The mutator that mutates the other mutator
Nature Medicine, 1996Microsatellite mutations are useful markers of both tumor clonality and genomic instability but the origin of the mutator mutations responsible is still not well understood (pages 676–681).
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Characterization of the mutator mutation mut5-1
Molecular and General Genetics MGG, 1979The mutator mutation mut5-1 has been characterized with respect to a range of parameters which have been used to describe DNA repair mutants of yeast. No marked effect of the mutation on UV-mutability at lower doses was apparent. Diploids homozygous for the mutation are deficient in UV-induced recombination between the alleles his1-1 and hist1-315 ...
D P, Morrison, P J, Hastings
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Mutation Detection and Mutation Databases
cclm, 1998AbstractDetection of mutations in genes is vital throughout biology, however, this activity is time-consuming, expensive and requires a high degree of skill. This is unsatisfactory in a field which is increasing importance. Around 10–12 methods are commonly used with some predominating.
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Nature, 1991
The detection and characterization of mutations in genes has become a major area of interest in many areas of biology. Such variation may account for speciation, tumour formation, drug resistance, as well as the more obvious nature of inherited disease.
R G, Cotton, A D, Malcolm
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The detection and characterization of mutations in genes has become a major area of interest in many areas of biology. Such variation may account for speciation, tumour formation, drug resistance, as well as the more obvious nature of inherited disease.
R G, Cotton, A D, Malcolm
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Directional mutation pressure, mutator mutations, and dynamics of molecular evolution
Journal of Molecular Evolution, 1993Using a general form of the directional mutation theory, this paper analyzes the effect of mutations in mutator genes on the G+C content of DNA, the frequency of substitution mutations, and evolutionary changes (cumulative mutations) under various degrees of selective constraints.
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Journal of Theoretical Biology, 2003
A traditional picture of evolutionary dynamics with constant fitness is that of genomes living in sequence space and adapting on fitness landscapes. Mutation rates are considered to be constant or externally regulated. If, however, we take into account that genomes also encode for enzymes that perform replication and error correction, then individual ...
Sasaki, Akira, Nowak, Martin A.
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A traditional picture of evolutionary dynamics with constant fitness is that of genomes living in sequence space and adapting on fitness landscapes. Mutation rates are considered to be constant or externally regulated. If, however, we take into account that genomes also encode for enzymes that perform replication and error correction, then individual ...
Sasaki, Akira, Nowak, Martin A.
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1978
With the exception of repair mutagenesis, which was reviewed two years ago (RHEASE, 3), the investigations of the basic molecular mechanisms of mutation induction by chemical substances seem to have reached a certain saturation level. The different types of mutations like transitions, transversions, deletions, frameshift mutations, backbone breakage ...
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With the exception of repair mutagenesis, which was reviewed two years ago (RHEASE, 3), the investigations of the basic molecular mechanisms of mutation induction by chemical substances seem to have reached a certain saturation level. The different types of mutations like transitions, transversions, deletions, frameshift mutations, backbone breakage ...
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Dermatologic Clinics, 2010
A mutation is an event that produces heritable changes in the DNA. There are many different types of mutations, including point mutations (changes that imply loss, duplication, or alterations of small DNA segments, often involving a single or a few nucleotides) and major DNA changes (loss, duplication, or rearrangements of entire genes or of gene ...
Daniele, Castiglia, Giovanna, Zambruno
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A mutation is an event that produces heritable changes in the DNA. There are many different types of mutations, including point mutations (changes that imply loss, duplication, or alterations of small DNA segments, often involving a single or a few nucleotides) and major DNA changes (loss, duplication, or rearrangements of entire genes or of gene ...
Daniele, Castiglia, Giovanna, Zambruno
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Mutational analysis: new mutations
1995Abstract In the last few years the search for mutations and sequence polymorphisms has been dramatically accelerated by the use of PCR and subsequently by direct sequencing of PCR products (1, 2). In spite of these powerful new methods, direct sequencing is not always practicable in detecting mutations because they may be positioned ...
K Michaelides +4 more
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