Results 51 to 60 of about 1,539,409 (267)

Hereditary alpha-tryptasemia and monoclonal mast cell disorders

Frontiers in Allergy
Monoclonal mast cell disorders (mMCD), including systemic mastocytosis, are characterized by the abnormal accumulation of clonal mast cells, often leading to elevated baseline serum tryptase (bST) levels. Thus, bST evaluation is useful for the diagnosis,
Yannick Chantran, Yannick Chantran, Yannick Chantran, Michel Arock, Michel Arock   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Mutational landscape of epidermoid carcinoma of the penis in a Brazilian cohort [PDF]

Exploration of Targeted Anti-tumor Therapy
Aim: Penile cancer (PeCa) is a rare malignancy strongly associated with poor genital hygiene and is more prevalent in regions with low socioeconomic status.
Renato Mendes Rossi De Lucca, Danielle Barbosa Brotto, Claudia Tarcila Gomes Sares, Kelly Gomes Duarte, Wilson Araujo Silva Junior, Philippe E. Spiess, Shahrokh F. Shariat, Natália Dalsenter Avilez, Caio de Oliveira, Leonardo O. Reis, Rodolfo Borges dos Reis   +10 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Un point de vue néoréaliste en épistémologie du journalisme

Sur le Journalisme, 2017
Il peut y avoir un certain intérêt à traiter de la nature du journalisme non pas pour en circonscrire les limites, mais afin de mettre au jour les présuppositions qui président à sa pratique. C’est une proposition en ce sens qui est ici formulée.
Gilles Gauthier
doaj  

Diagnostic accuracy of the lactate stress test for detecting mitochondrial disorders: Systematic review and meta-analysis

Heliyon
Due to their variable phenotypes, mitochondrial disorders (MDs) can be difficult to diagnose. The absolute load lactate stress test (LSTA) and the relative load lactate stress test (LSTR) have been shown to be useful screening tools for the detection of ...
Sara El Guessabi, Redouane Abouqal, Azeddine Ibrahimi, Ghizlane Zouiri, Fatima Sfifou, Josef Finsterer, Yamna Kriouile   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

El conjunto habitacional Las Américas, un laboratorio para la edificación de una microsociedad

Alteridades, 2014
En un reciente conjunto habitacional de interés social ubicado en Ecatepec, Estado de México, se observan condiciones de vida y patrones de movilidad e inmovilidad que generan cierto aislamiento de sus residentes, haciendo de éste un territorio de vida ...
Céline Jacquin
doaj  

Partial Purine Nucleoside Phosphorylase Deficiency Helps Determine Minimal Activity Required for Immune and Neurological Development

Frontiers in Immunology, 2020
Introduction: Complete or near complete absence of the purine nucleoside phosphorylase (PNP) enzyme causes a profound T cell immunodeficiency and neurological abnormalities that are often lethal in infancy and early childhood.
Eyal Grunebaum, Eyal Grunebaum, Nicholas Campbell, Matilde Leon-Ponte, Xiaobai Xu, Hugo Chapdelaine   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source