Results 71 to 80 of about 1,539,409 (267)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Mutations in RNA‐dependent RNA polymerase could be major cause of high pandemic potential of SARS‐CoV‐2: An in‐silico study

Indonesian Journal of Biotechnology
Human coronaviruses (HCoVs) are responsible for mild common cold to severe pneumonia‐like symptoms in infected individuals. The first HCoV was HCoV‐229E, discovered in 1962 in the US, which causes moderate symptoms.
Bhawna Sharma, Bennet Angel, Annette Angel, Vinod Joshi, Shareef Mohammed Buvvaji, Neha Singh, Khushbu Kumari, Aarya Chitransh, Poorna Khaneja, Devendra Kumar   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Introductory Paper: Cultures Under Negotiation: Discourse, Identity, And The Reconfiguration Of Meaning In Global Contexts

The Journal of Studies in Language, Culture and Society
This special issue brings together rich contributions that collectively interrogate the conditions under which cultures are produced, sustained, contested, and reconfigured in an increasingly mediated and interconnected world.
Philippe Viallon, Nadia Idri, Leila Hammoud   +2 more
doaj   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

EndoGene database: reported genetic variants for 5,926 Russian patients diagnosed with endocrine disorders

Frontiers in Endocrinology
IntroductionEndocrine system disorders are a serious public health burden and can be caused by deleterious genetic variants in single genes or by the combined effects of multiple variants along with environmental and lifestyle factors.MethodsThe EndoGene
Anton A. Buzdin, Anton A. Buzdin, Anton A. Buzdin, Anton A. Buzdin, Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Sergey A. Roumiantsev, Aleksandra G. Emelyanova, Aleksandra G. Emelyanova, Olga O. Golounina, Polina A. Pugacheva, Polina A. Pugacheva, Daniil V. Luppov, Daniil V. Luppov, Anastasia V. Kuzminyh, Arseniya O. Alexeeva, Arseniya O. Alexeeva, Anna A. Emelianova, Anna A. Emelianova, Alexey L. Novoselov, Alina Matrosova, Anastasia A. Slepukhina, Sergey V. Popov, Evgeniya V. Plaksina, Vasiliy M. Petrov, Anastasia R. Guselnikova, Anastasia D. Shagina, Maria V. Suntsova, Victoriya V. Zakharova, Zhanna E. Belaya, Maria V. Vorontsova, Maria V. Vorontsova, Galina A. Melnichenko, Natalia G. Mokrysheva, Vladimir P. Chekhonin, Ivan I. Dedov   +35 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Mutations at the Level of the Measures Adopted by Monetary Authorities [PDF]

Risk in Contemporary Economy, 2011
Following the intensification of the international financial crisis in autumn 2008 the functioning of the financial system was seriously hindered. Central banks around the world responded firmly by lowering their key interest rates to historically low ...
Marius Constantin APOSTOAIE, Stefan MATEI   +1 more
doaj