Results 71 to 80 of about 482,704 (293)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani   +8 more
wiley   +1 more source

Comment on "Statistical Distribution for Generalized Ideal Gas of Fractional-Statistics Particles", Phys. Rev. Lett. {\bf 73}, 922 (1994)

open access: yes, 2009
In Phys. Rev. Lett. 67, 937 (1991) [1], Haldane introduced the fruitful concept of fractional exclusion statistics (FES). One of the most influential papers in which the thermodynamics of FES systems was deduced is Y.-S. Wu, Phys. Rev. Lett.
Anghel, Dragoş-Victor
core   +1 more source

Brief Announcement: Fast and Scalable Group Mutual Exclusion [PDF]

open access: yes, 2018
The group mutual exclusion (GME) problem is a generalization of the classical mutual exclusion problem in which every critical section is associated with a type or session. Critical sections belonging to the same session can execute concurrently, whereas
Gokhale, Shreyas, Mittal, Neeraj
core   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt   +5 more
wiley   +1 more source

Binary Bose-Einstein Condensate Mixtures in Weakly and Strongly Segregated Phases

open access: yes, 1998
We perform a mean-field study of the binary Bose-Einstein condensate mixtures as a function of the mutual repulsive interaction strength. In the phase segregated regime, we find that there are two distinct phases: the weakly segregated phase ...
B. D. Esry   +13 more
core   +1 more source

Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Antinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non‐AI conditions is associated with disease.
Matthew Chung   +7 more
wiley   +1 more source

Optimal nodes selection in wireless sensor and actor networks based on prioritized mutual exclusion approach

open access: yesKuwait Journal of Science, 2016
In this research paper we study the problem of mutual exclusionin the context ofwireless sensor and actor network (WSAN) and propose two novel approaches tosolve it.
VIRENDER RANGA   +2 more
doaj  

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