Results 91 to 100 of about 1,330,365 (275)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Constructing more informative plant-pollinator networks : visitation and pollen deposition networks in a heathland plant community [PDF]

, 2015
Interaction networks are widely used as tools to understand plant–pollinator communities, and to examine potential threats to plant diversity and food security if the ecosystem service provided by pollinating animals declines.
Baldock, Katherine C. R., Willmer, P. G., Ballantyne, Gavin, Baldock, Katherine C R, Willmer, Patricia Gillian, Willmer, P G, Ballantyne, G, Ballantyne, G., Baldock, Katherine, Ballantyne, Gavin Andrew, Baldock, Katherine C.R., Willmer, Pat G.   +11 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A role for parasites in stabilising the fig-pollinator mutualism [PDF]

, 2008
Mutualisms are interspecific interactions in which both players benefit. Explaining their maintenance is problematic, because cheaters should outcompete cooperative conspecifics, leading to mutualism instability. Monoecious figs (Ficus) are pollinated by
Crozier, Ros H., Dunn, Derek W., Yu, Douglas W., Segar, Simon T., Simon T Segar, Dunn Derek W, Ruth Chan, Ridley Jo, Cook James M, Derek W Dunn, Segar Simon T, Cook, James M., Ridley, Jo, James M Cook, Douglas W Yu, Yu Douglas W, Ross H Crozier, Jo Ridley, Chan, Ruth, Chan Ruth, Crozier, Ross H., Crozier Ross H, Segar, Simon, Yu, D. W., Crozier, R. H., Dunn, D. W., Chan, R., Segar, S. T., Ridley, J., Cook, J. M.   +29 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Insights into the Genomics of Clownfish Adaptive Radiation: Genetic Basis of the Mutualism with Sea Anemones

, 2019
International audienceClownfishes are an iconic group of coral reef fishes, especially known for their mutualism with sea anemones. This mutualism is particularly interesting as it likely acted as the key innovation that triggered clownfish adaptive ...
Marcionetti, Anna, Marcionetti, A., Salamin, Nicolas, Salis, P., Salamin, N., Salis, Pauline, Laudet, Vincent, Rossier, V., Rossier, Victor, Laudet, V., Roux, Natacha, Roux, N.   +11 more
core   +1 more source

Multiple levels of synergistic collaboration in termite lignocellulose digestion. [PDF]

PLoS ONE, 2011
In addition to evolving eusocial lifestyles, two equally fascinating aspects of termite biology are their mutualistic relationships with gut symbionts and their use of lignocellulose as a primary nutrition source.
Michael E Scharf, Zachary J Karl, Amit Sethi, Drion G Boucias   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Conserved Cell Growth Cycle Can Account for the Environmental Stress Responses of Divergent Eukaryotes [PDF]

, 2012
The respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC).
Airoldi, Edoardo|, Airoldi, E.M., Airoldi, EM, Airoldi, Edoardo M, Botstein, D., van Oudenaarden, Alexander, Airoldi, Edoardo, Van Oudenaarden, A, Botstein, David, Slavov, Nikolai G, Botstein, D, Slavov, N., Airoldi, Edoardo M., Slavov, N, van Oudenaarden, A., Slavov, Nikolai   +15 more
core   +1 more source

Epichloë Fungal Endophytes—From a Biological Curiosity in Wild Grasses to an Essential Component of Resilient High Performing Ryegrass and Fescue Pastures

Journal of Fungi, 2020
The relationship between Epichloë endophytes found in a wide range of temperate grasses spans the continuum from antagonistic to mutualistic. The diversity of asexual mutualistic types can be characterised by the types of alkaloids they produce in planta.
John R. Caradus, Linda J. Johnson
doaj   +1 more source