Results 81 to 90 of about 1,330,365 (275)
The International Journal of Developmental Biology, 2009 This paper presents a novel perspective of Robotic Stem Cells (RSCs), defined as the basic non-biological elements with stem cell like properties that can self-reorganize to repair damage to their swarming organization. Self here means that the elements can autonomously decide and execute their actions without requiring any preset triggers, commands ...
Michael, Rubenstein +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Prokaryotes versus Eukaryotes: Who is hosting whom?
Frontiers in Veterinary Science, 2014 Microorganisms represent the largest component of biodiversity in our world. For millions of years, prokaryotic microorganisms have functioned as a major selective force shaping eukaryotic evolution.
Guillermo eTellez
doaj +1 more source
A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains co-occurrence [PDF]
Genome Biology, 2016 Abstract Just like recurrent somatic alterations characterize cancer genes, mutually exclusive or co-occurring alterations across genes suggest functional interactions. Identifying such patterns in large cancer studies thus helps the discovery of unknown interactions. Many studies use Fisher’s exact test or simple permutation procedures
Canisius, Sander (author) +2 more
openaire +5 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Biology of Mutualisms by D. H. Boucher
, 1989 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +1 more source
How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations? [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2016 Abstract Large-scale analyses of cancer genomes are revealing patterns of mutations that suggest biologically significant ideas about many aspects of cancer, including carcinogenesis, classification, and preventive and therapeutic strategies. Among those patterns is “mutual exclusivity”, a phenomenon observed when two
Varmus, Harold +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Ants mediate the structure of phytotelm communities in an ant-garden bromeliad [PDF]
, 2010 The main theories explaining the biological diversity of rain forests often confer a limited understanding of the contribution of interspecific interactions to the observed patterns.
Céréghino, Régis +3 more
core +1 more source
Engineering MicrobiologyInvestigating ecological interactions within microbial ecosystems is essential for enhancing our comprehension of key ecological issues, such as community stability, keystone species identification, and the manipulation of community structures.
Wei Jiang +5 more
doaj +1 more source