Results 101 to 110 of about 1,568,516 (299)
Os tumores orais em cães representam cerca de 6% de todas as neoplasias dessa espécie. O objetivo deste trabalho foi realizar um estudo epidemiológico dos cães com tumores orais atendidos no Hospital de Clínicas Veterinárias da Universidade Federal do ...
Cristiano Gomes +7 more
doaj +1 more source
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Prevalence survey of musculoskeletal and connective tissue disorders in the Russian Federation
Diseases of the musculoskeletal system and connective tissues are becoming more and more common. As these disorders are associated with temporary or permanent disability as well as a costly treatment, this socially-significant issue requires close ...
T. A. Oleynikova +2 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
We have developed a combined photolithography and electron-beam lithography fabrication process for sub-\mum to \mum-size Nb/Al-AlOx/Nb Josephson junctions.
+12 more
core +1 more source
The aim of this paper is to go deeper into the questions of MV-algebras provided with square roots. Höhle proposed a classification of MV-algebras with square roots, introducing the strict MV-algebras and proving that every MV-algebra with square roots is exactly a Boolean algebra, or a strict algebra, or isomorphic to the product of both. Due to their
openaire +2 more sources
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DI NOLA, Antonio +2 more
openaire +4 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source

