Results 101 to 110 of about 218,624 (251)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Operasi closure pada mv-aljabar [PDF]

, 2022
MV-aljabar M adalah struktur aljabar dengan dua operasi biner yang memenuhi aksioma-aksioma tertentu pada MV-aljabar. Dalam MV-aljabar didefinisikan suatu Ideal dan dalam suatu Ideal MV-aljabar, dibentuk suatu himpunan yang berisikan ideal-ideal dari MV-
Ariyanti, Putri Widiya
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Condition Assessment of Field-Aged Composite Insulators Following Incidents of Insulator Flashunder

Energies
A condition assessment of a group of field-aged insulators operated for only 6 years on the island of Rhodes after incidents of intense electrical activity is presented in this paper.
Nikolaos Mavrikakis, Kiriakos Siderakis
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Cistotomia para remoção de urólitos vesicais em um suíno adulto da raça Moura: relato de caso

Medicina Veterinária
A urolitíase é um processo patológico multifatorial, muito comum e frequente em suínos de todo o mundo, caracterizado pela presença de urólitos no trato urinário.
Caio Veloso Silva, Gilberto Serighelli Júnior, Juliana Sperotto Brum, Karine Kulik, Lucas Augusto dos Santos Flores, Maressa Mantovani de Lara Martins, Adrya Hardt Faria dos Santos, Juan Carlos Duque Moreno, Peterson Triches Dornbusch, Ivan Roque de Barros Filho   +9 more
doaj   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

La responsabilidad del transportista en caso de accidente en transporte ferroviario

, 2016
El trabajo analiza el régimen de responsabilidad en caso de accidente en transporte ferroviario contenido en las RU CIV; su incorporación en la UE mediante el Reglamento (CE) no 1371/2007; y la adaptación e interpretación de dichas normas en los ...
Petit Laval, MV, Rosafio, E
core   +1 more source