Results 111 to 120 of about 91,972 (285)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

International consensus guidance for management of myasthenia gravis

Neurology, 2016
Objective: To develop formal consensus-based guidance for the management of myasthenia gravis (MG). Methods: In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 ...
D. Sanders, G. Wolfe, M. Benatar, A. Evoli, N. Gilhus, I. Illa, N. Kuntz, J. Massey, A. Melms, H. Murai, M. Nicolle, Jacqueline A Palace, D. Richman, J. Verschuuren, P. Narayanaswami   +14 more
semanticscholar   +1 more source

Correlation of Quantitative Myasthenia Gravis and Myasthenia Gravis Activities of Daily Living scales in the MGTX study

Muscle and Nerve, 2020
Quantitative Myasthenia Gravis (QMG) and Myasthenia Gravis Activities of Daily Living (MG‐ADL) scales were compared using the data from the Thymectomy Trial in Non‐Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy (MGTX) study.
Tarrant O. McPherson, I. Aban, P. Duda, R. Farzaneh-Far, G. Wolfe, H. Kaminski, G. Cutter, Ikjae Lee   +7 more
semanticscholar   +1 more source

Exploring the depths of IgG4: insights into autoimmunity and novel treatments

Frontiers in Immunology
IgG4 subclass antibodies represent the rarest subclass of IgG antibodies, comprising only 3-5% of antibodies circulating in the bloodstream. These antibodies possess unique structural features, notably their ability to undergo a process known as fragment-
Selen Ünlü, Selen Ünlü, Blanca G. Sánchez Navarro, Elif Cakan, Daniel Berchtold, Rafael Meleka Hanna, Secil Vural, Secil Vural, Atay Vural, Atay Vural, Andreas Meisel, Miriam L. Fichtner, Miriam L. Fichtner   +12 more
doaj   +1 more source

Myasthenia Gravis Related to Thymic Carcinoma: A Case Study

The Thoracic & Cardiovascular Surgeon Reports, 2020
Myasthenia gravis and thymoma are often presented in association with ∼10% of myasthenic cases having concomitant thymoma. Thymic carcinoma is one of the rarest/aggressive human epithelial tumors and has no correlation with myasthenia gravis hitherto ...
Daniel Thomas Pereira Lopes, Samila Marissa Pinheiro Gomes, Sheila Aparecida Coelho Siqueira, Fernando Pereira Frassetto, Pedro Henrique Martins Arruda Sampaio, Cristiane Araujo Martins Moreno, Maria Sheila Guimarães Rocha, Eduardo Paula Estephan   +7 more
doaj   +1 more source

Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status. [PDF]

, 2007
Am J Pathol. 2007 Sep;171(3):893-905. Epub 2007 Aug 3. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status.
Adams, Alexander Marx, Angela Vincent, Aurea Canelhas, B. Paul Morgan, Beeson, Berrih, Castleman, Cole, Dashiell, Daveau, Davies, Drachman, Engel, Erik Niks, Evoli, Flores, Fosbrink, Francesco Scaravilli, French, Gasque, Graus, Hageman, Hoch, Hsi, Jan J.G.M. Verschuuren, Kaminski, Kaminski, Kyewski, Lampert, Lauriola, Leite, Lin, MacLennan, MacLennan, Margaret Jones, Maria I. Leite, Mason, Matthews, McConville, Meraouna, Monsinjon, Morgan, Morgan, Morgan, Nakano, Navenot, Nick Willcox, Ohta, Philipp Ströbel, Plested, Pratt, Ralf Gold, Roxanis, Roxanis, Rus, Safar, Sanders, Schluep, Schluep, Shiono, Sims, Sonia Berrih-Aknin, Spreadbury, Sprott, Tzartos, van Beek, Vincent, Vincent, Wakkach, Wekerle, Zhang   +71 more
core   +2 more sources

Teratoid Hepatoblastoma: Clinicopathologic Features and Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Teratoid hepatoblastoma (HB) is a rare histologic subtype of the most common pediatric liver cancer. Understanding of the clinicopathologic features and outcomes of patients with this disease is currently limited. Methods Multi‐institution, retrospective chart review was conducted to compare 20 children with teratoid HB to 129 ...
Brian T. Hickner, Andres F. Espinoza, Soo Jin Cho, Stephen Sarabia, Martin Urbicain, Ann Wang, Sanjeev A. Vasudevan, Dolores H. López‐Terrada, Kalyani R. Patel   +8 more
wiley   +1 more source

A Review of Psychiatric Comorbidity in Myasthenia Gravis

Cureus, 2020
This study aimed to review studies focused on the affective comorbidities associated with myasthenia gravis and to determine the extent to which neuromuscular treatment modalities address non-somatic aspects of autoimmune myasthenia gravis.
Christina Law, C. Flaherty, S. Bandyopadhyay   +2 more
semanticscholar   +1 more source

Design of and Early Insights From a Generalized Myasthenia Gravis Patient Engagement Research Council

Health Science Reports
Background and Aims An exploratory focus group study was conducted to better understand the needs of patients living with generalized myasthenia gravis (gMG).
Gabrielle Geonnotti, Jacqueline Pesa, Wesley Peters, Melina Taylor, Zia Choudhry, Oluyemisi Falope, Marquetta Price, Lucy Baxter, Bruce West, Lisa Shea   +9 more
doaj   +1 more source

Malignancies and immunoglobulin G4‐related disease

Rheumatology &Autoimmunity, EarlyView.
Immunoglobulin G4‐related disease (IgG4‐RD) is associated with increased cancer risk. Malignancies affect both IgG4‐RD involved organs, such as the lung, pancreas, bile duct, and prostate, and noninvolved organs, such as the gastrointestinal duct. B‐cell neoplasms constitute a proportion of the malignancies linked to this disease.
Jingna Li, Wen Zhang
wiley   +1 more source