Results 111 to 120 of about 80,519 (274)

Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis [PDF]

, 2012
Background Myasthenia gravis (MG) and animal model of experimental autoimmune myasthenia gravis (EAMG) is the most common autoimmune disorder of neuromuscular transmission. The disease is caused by the breakdown of the acetylcholine receptor (AChR) which
Soltys, Jindrich, Wu, Xiaobo
core   +3 more sources

Confronting medical grifting: Fraudulent and unproven products and interventions in apheresis, transfusion and biotherapies

British Journal of Haematology, EarlyView.
A basic overview of medical grifting for haematologists with practical guidance in identification and tips for management. Summary Medical scams or grifting has long been a societal issue, though in recent years, the problem has become increasingly mainstream, especially as it relates to transfusion medicine, apheresis and biotherapies.
Brian D. Adkins, Sheharyar Raza, Victoria Costa, Elizabeth S. Allen, Laura D. Stephens, Jennifer S. Woo, Garrett S. Booth, Jeremy W. Jacobs   +7 more
wiley   +1 more source

Study on the clinical and electrophysiological characteristics of nerve function in myasthenia gravis patients in Vietnam

SAGE Open Medicine
Background: In Vietnam, there is limited research on the role of nerve conduction in myasthenia gravis and its association with clinical features. Objective: This study aims to describe the electrophysiological features in patients with myasthenia gravis.
Tho Kieu Anh Pham, Phuong Van Pham, Tung Dinh Le, Binh Thanh Nguyen, Trung Kien Nguyen, Tam Thai Thanh Tran, Sam Phan Hai Nguyen, Minh Van Le   +7 more
doaj   +1 more source

Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial

BJU International, Volume 135, Issue 4, Page 638-647, April 2025.
Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui, Marlene Elmelund, Niels Klarskov   +2 more
wiley   +1 more source

Creation of a 13-Item Bedside Dysphagia Screening Test [PDF]

, 2011
Dysphagia is a common problem that affects people with many health conditions and that can have serious complications. Various dysphagia screening tests exist; however, their creation was associated with certain weaknesses, e.g.
Ehler, Edvard, Mandysova, Petra, Černý, Michal, Škvrňáková, Jana   +3 more
core   +1 more source

Eculizumab improves fatigue in refractory generalized myasthenia gravis [PDF]

, 2019
Purpose: To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using the Quality of Life in Neurological Disorders (Neuro-QOL) Fatigue ...
Andersen, Henning, De Bleecker, Jan, Howard, James F, Jr, Mantegazza, Renato, O'Brien, Fanny, Patra, Kaushik, REGAIN Study Group, the, Wang, Jing Jing   +7 more
core   +2 more sources

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Distribution of Ectopic Germinal Centers in Thymic Epithelial Tumors and Their Relationship With Thymic Involution

Cancer Science, EarlyView.
In this study, we demonstrate that ectopic germinal centers were observed in less involuted thymus of thymic epithelial tumors positive for antiacetylcholine receptor antibodies, associating their presence with higher antibody titers and supporting the need for at least a total thymectomy in younger patients. ABSTRACT Ectopic germinal centers (GCs) are
Tatsuo Furuya, So Tando, Hiroshi Ogi, Masanori Shimomura, Satoru Okada, Shunta Ishihara, Chiaki Nakazono, Kyoko Itoh, Masayoshi Inoue   +8 more
wiley   +1 more source

Myasthenia gravis: analysis of serum autoantibody reactivities to 1827 potential human autoantigens by protein macroarrays.

PLoS ONE, 2013
BackgroundMyasthenia gravis is a disorder of neuromuscular transmission associated with autoantibodies against the nicotinic acetylcholine receptor. We have previously developed a customized protein macroarray comprising 1827 potential human autoantigens,
Anne Becker, Nicole Ludwig, Andreas Keller, Björn Tackenberg, Christian Eienbröker, Wolfgang H Oertel, Klaus Fassbender, Eckart Meese, Klemens Ruprecht   +8 more
doaj   +1 more source

Impact of Prior Intravenous Immunoglobulin and Plasmapheresis on Eculizumab or Ravulizumab Treatment for Generalized Myasthenia Gravis: An Analysis of the MG SPOTLIGHT Registry

Clinical and Experimental Neuroimmunology, EarlyView.
ABSTRACT Objective The complement component 5 inhibitor therapies (C5ITs) eculizumab and ravulizumab are approved for the treatment of generalized myasthenia gravis (gMG). We evaluated the real‐world effectiveness and safety of eculizumab and ravulizumab in patients with gMG with or without prior intravenous immunoglobulin (IVIg) or plasma exchange ...
Akiyuki Uzawa, Ema Rodrigues, Hiroyuki Murai   +2 more
wiley   +1 more source