Results 151 to 160 of about 35,534 (303)

Regulatory effect of C12ORF66 on viability of MYCN amplified high-risk neuroblastoma cells [PDF]

Jichu yixue yu linchuang
Objective To explore the effect of open reading frame 66 (C12ORF66) located at chromosome 12 on the viability of MYCN amplified NB cell lines. Methods DDatasets GSE16476 and GSE49710 in R2 database were analyzed for expression level of C12ORF66 in MYCN
JIA Anna, ZHAN Shijia, ZHANG Xuan, GUO Jinxin, YU Yongbo, GUO Yongli, CHANG Yan
doaj   +1 more source

An Algorithm for Cellular Reprogramming

, 2017
The day we understand the time evolution of subcellular elements at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away.
Bloch, Anthony, Brockett, Roger, Brown, Markus, Chen, Haiming, Muir, Lindsey, Patterson, Geoff, Rajapakse, Indika, Ronquist, Scott   +7 more
core   +1 more source

MYCN Gene Copy Number Status Detected by FISH Method and Its Correlation with Outcome and Clinicopathological Variables in Childhood Neuroblastoma [PDF]

Middle East Journal of Cancer
Background: Neuroblastoma is the most common extracranial solid tumor in children. MYCN gene amplification (MNA) is an independent prognostic factor for rapid tumor progression and poor prognosis, regardless of age and clinical stage.
Mahdi Shahriari, Akbar Safaei, Parvaneh Davoudi, Bozorgmehr Hedayati   +3 more
doaj   +1 more source

Bromodomain containing 4 (BRD4); v-myc myelocytomatosis viral related oncogene neuroblastoma derived ( MYCN ; NMYC ) [PDF]

, 2013

openalex   +1 more source

Supplementary Methods and Figure Legend from NLRR1 Enhances EGF-Mediated <i>MYCN</i> Induction in Neuroblastoma and Accelerates Tumor Growth <i>In Vivo</i> [PDF]

, 2023
Shamim Hossain, Atsushi Takatori, Yohko Nakamura, Yusuke Suenaga, Takehiko Kamijo, Akira Nakagawara   +5 more
openalex   +1 more source

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

Nature Cell Biology, 2010
MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased ...
Li Ma, Jennifer J Young, Harsha K. Prabhala, Elizabeth Pan, P. Mestdagh, D. Muth, J. Teruya-Feldstein, Ferenc Reinhardt, T. Onder, Scott Valastyan, F. Westermann, F. Speleman, J. Vandesompele, R. Weinberg   +13 more
semanticscholar   +1 more source

Genome-Wide Survey of MicroRNA - Transcription Factor Feed-Forward Regulatory Circuits in Human

, 2009
In this work, we describe a computational framework for the genome-wide identification and characterization of mixed transcriptional/post-transcriptional regulatory circuits in humans. We concentrated in particular on feed-forward loops (FFL), in which a
Alvarez-Garcia, Angela Re, Calin, Chan, Chen, Corà, Corà, Corà, Daniela Taverna, Davide Corá, Elnitski, Esquela-Kerscher, Filipowicz, Gershengom, Griffiths-Jones, Gudmundsson, He, Hornstein, Hubbard, Iorio, Joglekar, John, Konagurthu, Krek, Ladd, Lai, Landgraf, Lee, Lewis, Lewis, Liu, Loots, Martinez, Matys, Mazurie, Michele Caselle, Milo, Nielsen, O’Donnell, Pan, Pesole, Phan, Saini, Shalgi, Shen-Orr, Tsang, Wagner, Wilkerson, Xie, Zeller, Zhang, Zhao   +51 more
core   +1 more source

miR‐15a‐5p, miR‐15b‐5p, and miR‐16‐5p inhibit tumor progression by directly targeting MYCN in neuroblastoma

Molecular Oncology, 2019
Neuroblastoma (NB) is the most common extracranial solid malignancy in children. Despite current aggressive treatment regimens, the prognosis for high‐risk NB patients remains poor, with the survival of less than 40%.
Srinivas Chava, C. Reynolds, A. Pathania, S. Gorantla, L. Poluektova, D. Coulter, Subash C. Gupta, M. Pandey, K. Challagundla   +8 more
semanticscholar   +1 more source

Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.

PLoS ONE, 2012
MYCN amplification occurs in about 20-25% of human neuroblastomas and characterizes the majority of the high-risk cases, which display less than 50% prolonged survival rate despite intense multimodal treatment. Somehow paradoxically, MYCN also sensitizes
Veronica Veschi, Marialaura Petroni, Beatrice Cardinali, Carlo Dominici, Isabella Screpanti, Luigi Frati, Armando Bartolazzi, Alberto Gulino, Giuseppe Giannini   +8 more
doaj   +1 more source

Chromosome band 11q23 deletion predicts poor prognosis in bone marrow metastatic neuroblastoma patients without MYCN amplification

Cancer Communications, 2019
Background Interphase fluorescence in situ hybridization (FISH) of bone marrow cells has been confirmed to be a direct and valid method to assess the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) amplification in ...
Zhi-Xia Yue, Tian-Yu Xing, Chao Gao, Shu-Guang Liu, Wen Zhao, Qian Zhao, Xi-Si Wang, Mei Jin, Xiao-Li Ma   +8 more
doaj   +1 more source