Results 271 to 280 of about 35,534 (303)

MYCN gain and MYCN amplification in a stage 4S neuroblastoma

Cancer Genetics and Cytogenetics, 2003
Stage 4S neuroblastoma is a disease associated with spontaneous regression and good survival. We present a patient whose evolution has shown the variety and complexity of this disease in infants. Biologic factors, such as ploidy, MYCN copy number, loss of 1p36, and other chromosomal gains and losses were determined.
Rosa, Noguera, Adela, Cañete, Antonio, Pellín, Amparo, Ruiz, María, Tasso, Samuel, Navarro, Victoria, Castel, Antonio, Llombart-Bosch   +7 more
openaire   +2 more sources

Locoregional MYCN‐amplified neuroblastoma

Pediatric Blood & Cancer, 2012
AbstractMYCN‐amplification is strongly associated with other high‐risk prognostic factors and poor outcome in neuroblastoma. Infrequently, amplification of MYCN has been identified in localized tumors with favorable biologic features. Outcome for these children is difficult to predict and optimal treatment strategies remain unclear. We report a 5‐month‐
Morales La Madrid A, Volchenboum S, Gastier-Foster JM, Pyatt R, Liu D, Pytel P, Lavarino C, Rodriguez E, Cohn SL   +8 more
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MYCN in neuronal tumours

Cancer Letters, 2004
MYCN is a member of the MYC family of oncogenes that encode nuclear proteins serving as transcription factors. Activation of MYC family genes, usually by genetic damage with the consequence of enhanced expression of a wild-type protein, has been found to participate in human and animal cancers.
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MYC, MYCL, and MYCN as therapeutic targets in lung cancer

Expert opinion on therapeutic targets, 2020
Introduction: Lung cancer is the leading cause of cancer-related mortality globally. Despite recent advances with personalized therapies and immunotherapy, the prognosis remains dire and recurrence is frequent.
D. Massó-Vallés, M. Beaulieu, L. Soucek   +2 more
semanticscholar   +1 more source

MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas

Human Cell
MYCN (master regulator of cell cycle entry and proliferative metabolism) gene amplification defines a molecular subgroup of spinal cord ependymomas that show high-grade morphology and aggressive behavior. Demonstration of MYCN amplification by DNA methylation or fluorescence-in situ hybridization (FISH) is required for diagnosis. We aimed to (i) assess
Divya, Mohan, Aruna, Nambirajan, Rafat, Malik, Agrima, Sharma, Vaishali, Suri, Kavneet, Kaur, Ramesh, Doddamani, Ajay, Garg, Subhash, Gupta, Supriya, Mallick, Mehar Chand, Sharma   +10 more
openaire   +2 more sources

MYCN Amplification by Differential PCR

Pediatric Hematology and Oncology, 1993
A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma by the technique of differential polymerase chain reaction (PCR). The technique is quicker than conventional Southern blotting techniques and does not require radioactive materials.
S N, Huddart, J R, Mann, A G, McGukin, R, Corbett   +3 more
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Secondary enucleated retinoblastoma with MYCN amplification

Ophthalmic Genetics, 2021
Background: Absence of RB1 mutation is rare in retinoblastoma and MYCN amplifications were recently identified in a subset of aggressive retinoblastomas occurring in infants. Here we describe not only the clinical phenotype of MYCN retinoblastoma at presentation, but also the tumor response to the first attempt of conservative management in this ...
Alexandre P, Moulin, Christina, Stathopoulos, Fabienne, Marcelli, Jacqueline, Schoumans Pouw, Maja, Beck-Popovic, Francis L, Munier   +5 more
openaire   +2 more sources

MYCN and MicroRNAs

2015
MicroRNAs (miRNAs) are small noncoding RNAs that downregulate translation of mRNAs into proteins by specifically binding the 3′-untranslated regions (UTRs).
Althoff, Kristina, Schulte, Johannes
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ALK pERKs Up MYCN in Neuroblastoma

Science Signaling, 2014
Identification of a crucial mediator between abnormally active ALK and MYCN reveals a potential combination therapy for several tumor types.
Lindner, Sven, Henssen, Anton, Astrahantseff, Kathy, Schulte, Johannes   +3 more
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MYCN AMPLIFICATION IN MEDULLOBLASTOMA

Pediatric Pathology & Molecular Medicine, 1998
Prominent neuronal differentiation and MYCN amplification occur only in a small percentage of medulloblastomas (primitive neuroectodermal tumor of the cerebellum). In this article, we describe two medulloblastomas that showed a striking degree of neuronal differentiation with islands of mature neurons associated with abundant neuropil.
Venita Jay, Paula Marrano, Maria Zielenska   +2 more
openaire   +2 more sources