Results 31 to 40 of about 18,634 (185)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Mycobacterium intracellulare M.i.198—A Promising Strain for Studying Pathogenesis of Nontuberculous Mycobacterial Pulmonary Disease (NTM‐PD)

Microbiology and Immunology, EarlyView.
ABSTRACT In this review, we introduce a promising strain for studying pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM‐PD), Mycobacterium intracellulare M.i.198. M.i.198 was isolated from a patient with progressive Mycobacterium avium‐intracellulare complex pulmonary disease (MAC‐PD) in whom surgical operation was required to ...
Yoshitaka Tateishi, Ryoji Maekura, Yukiko Nishiuchi, Sohkichi Matsumoto   +3 more
wiley   +1 more source

Strawberry micropropagation simplifies endomicrobiome and highlights potential for in vitro biotization with beneficial rhizobacteria

Plant Biology, EarlyView.
Prolonged in vitro micropropagation reshaped the strawberry endomicrobiome, reducing bacterial diversity and community complexity. Biotization with selected plant growth‐promoting bacteria partially compensated for these changes by improving plant performance and acclimatization, supporting microbiome‐assisted approaches for tissue culture systems ...
A. M. G. Sepúlveda, E. da Conceição Jesus, Y. C. Molina, V. H. Buttrós, L. Q. Carvalho, M. Pasqual, J. Dória   +6 more
wiley   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3002-3011, September 2026.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Attenuation Levels of Lung Fields in Quantitative Computed Tomography Evaluation Are Associated With Overall Survival and the Incidence of Acute Exacerbation in Combined Pulmonary Fibrosis and Emphysema: A Single‐Center Retrospective Observational Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Combined pulmonary fibrosis and emphysema (CPFE) is characterized by the coexistence of emphysematous lesions and fibrotic interstitial lung disease. We assessed the relationships of quantitative computed tomography (CT)‐derived measures with clinical characteristics and outcomes in CPFE.
Yusuke Suzuki, Yoshiaki Kitaguchi, Takumi Kinjo, Norihiko Goto, Masamichi Komatsu, Fumika Ueno, Yosuke Wada, Atsuhito Ushiki, Masanori Yasuo, Kiyoyasu Fukushima, Masayuki Hanaoka   +10 more
wiley   +1 more source

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, Volume 31, Issue 9, Page 1261-1272, September 2026.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source

The Antimycobacterial Activity, Toxicity and Chemical Composition of South African Propolis

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study presents one of the largest geographically diverse propolis collections reported globally, comprising 109 samples sourced from eight provinces across South Africa. The novelty of this work lies in the fact that it presents the first investigation of South African propolis against M. tuberculosis.
Nyiko F. Mzimba, Efficient N. Ncube, Elliasu Y. Salifu, Alvaro Viljoen, Bhavna Gordhan, Bavesh Kana, Sandy van Vuuren   +6 more
wiley   +1 more source

Mycobacterium avium Complex Disease

Microbiology Spectrum, 2017
ABSTRACT Despite the ubiqitous nature of Mycobacterium avium complex (MAC) organisms in the environment, relatively few of those who are infected develop disease. Thus, some degree of susceptibility due to either underlying lung disease or immunosuppression is required.
openaire   +2 more sources

Protein Extraction From Mycobacterium spp. for Identification by MALDI‐TOF Mass Spectrometry

Current Protocols, Volume 6, Issue 8, August 2026.
Abstract The identification of mycobacteria remains challenging due to the high species diversity within the genus and the lack of a molecular method able to identify them in a single assay. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) has been used as a rapid and promising alternative for bacterial ...
Lucas Evangelista Marques, Stephanie Chrystine Balestro Mota, Christoffel Opperman, Robin Mark Warren, Emilyn Costa Conceição, Cristina Viana‐Niero   +5 more
wiley   +1 more source

Palatal Actinomycosis and Kaposi Sarcoma in an HIV-Infected Subject with Disseminated Mycobacterium avium-intracellulare Infection

Case Reports in Medicine, 2012
Actinomyces and Mycobacterium avium-intracellulare are facultative intracellular organisms, members of the bacterial order actinomycetales. Although Actinomyces can behave as copathogen when anatomic barriers are compromised, its coinfection with ...
Yuria Ablanedo-Terrazas, Christopher E. Ormsby, Gustavo Reyes-Terán   +2 more
doaj   +1 more source